Fast 3D spatial EPR imaging using spiral magnetic field gradient

Yuanmu Deng, Sergy Petryakov, Guanglong He, Eric Kesselring, Periannan Kuppusamy, Jay L. Zweier

Research output: Contribution to journalArticle

Abstract

Electron paramagnetic resonance imaging (EPRI) provides direct detection and mapping of free radicals. The continuous wave (CW) EPRI technique, in particular, has been widely used in a variety of applications in the fields of biology and medicine due to its high sensitivity and applicability to a wide range of free radicals and paramagnetic species. However, the technique requires long image acquisition periods, and this limits its use for many in vivo applications where relatively rapid changes occur in the magnitude and distribution of spins. Therefore, there has been a great need to develop fast EPRI techniques. We report the development of a fast 3D CW EPRI technique using spiral magnetic field gradient. By spiraling the magnetic field gradient and stepping the main magnetic field, this approach acquires a 3D image in one sweep of the main magnetic field, enabling significant reduction of the imaging time. A direct one-stage 3D image reconstruction algorithm, modified for reconstruction of the EPR images from the projections acquired with the spiral magnetic field gradient, was used. We demonstrated using a home-built L-band EPR system that the spiral magnetic field gradient technique enabled a 4-7-fold accelerated acquisition of projections. This technique has great potential for in vivo studies of free radicals and their metabolism.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalJournal of Magnetic Resonance
Volume185
Issue number2
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Keywords

  • Fast 3D EPRI
  • Free radicals
  • Image reconstruction
  • Spiral magnetic field gradient
  • Trityl

ASJC Scopus subject areas

  • Molecular Biology
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Deng, Y., Petryakov, S., He, G., Kesselring, E., Kuppusamy, P., & Zweier, J. L. (2007). Fast 3D spatial EPR imaging using spiral magnetic field gradient. Journal of Magnetic Resonance, 185(2), 283-290. https://doi.org/10.1016/j.jmr.2007.01.001