Abstract
The role of Fas ligand (FasL) in physiologically limiting immune responses and maintaining immune-privileged sites has led to a body of research aiming to confer protection to allogeneic grafts by expressing FasL on the allogeneic tissue or by administrating FasL-transduced donor dendritic cells. In addition, several studies have used FasL to abrogate autoimmune responses. This review presents the results of these studies and discusses the problems associated with FasL usage.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 908-924 |
| Number of pages | 17 |
| Journal | Stem Cells |
| Volume | 22 |
| Issue number | 6 |
| State | Published - 2004 |
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Keywords
- Allogeneic
- Dendritic cells
- Fas ligand(FasL)
- gld
- Immune privilege
- lpr
- Tolerance
ASJC Scopus subject areas
- Cell Biology
Cite this
Fas ligand as a tool for immunosuppression and generation of immune tolerance. / Bohana-Kashtan, Osnat; Civin, Curt I.
In: Stem Cells, Vol. 22, No. 6, 2004, p. 908-924.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fas ligand as a tool for immunosuppression and generation of immune tolerance
AU - Bohana-Kashtan, Osnat
AU - Civin, Curt I.
PY - 2004
Y1 - 2004
N2 - The role of Fas ligand (FasL) in physiologically limiting immune responses and maintaining immune-privileged sites has led to a body of research aiming to confer protection to allogeneic grafts by expressing FasL on the allogeneic tissue or by administrating FasL-transduced donor dendritic cells. In addition, several studies have used FasL to abrogate autoimmune responses. This review presents the results of these studies and discusses the problems associated with FasL usage.
AB - The role of Fas ligand (FasL) in physiologically limiting immune responses and maintaining immune-privileged sites has led to a body of research aiming to confer protection to allogeneic grafts by expressing FasL on the allogeneic tissue or by administrating FasL-transduced donor dendritic cells. In addition, several studies have used FasL to abrogate autoimmune responses. This review presents the results of these studies and discusses the problems associated with FasL usage.
KW - Allogeneic
KW - Dendritic cells
KW - Fas ligand(FasL)
KW - gld
KW - Immune privilege
KW - lpr
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=8644250720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=8644250720&partnerID=8YFLogxK
M3 - Article
C2 - 15536183
AN - SCOPUS:8644250720
VL - 22
SP - 908
EP - 924
JO - Stem Cells
JF - Stem Cells
SN - 1066-5099
IS - 6
ER -