Fas ligand as a tool for immunosuppression and generation of immune tolerance

Osnat Bohana-Kashtan, Curt I. Civin

Research output: Contribution to journalArticle

Abstract

The role of Fas ligand (FasL) in physiologically limiting immune responses and maintaining immune-privileged sites has led to a body of research aiming to confer protection to allogeneic grafts by expressing FasL on the allogeneic tissue or by administrating FasL-transduced donor dendritic cells. In addition, several studies have used FasL to abrogate autoimmune responses. This review presents the results of these studies and discusses the problems associated with FasL usage.

Original languageEnglish (US)
Pages (from-to)908-924
Number of pages17
JournalStem Cells
Volume22
Issue number6
StatePublished - 2004

Keywords

  • Allogeneic
  • Dendritic cells
  • Fas ligand(FasL)
  • gld
  • Immune privilege
  • lpr
  • Tolerance

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Bohana-Kashtan, O., & Civin, C. I. (2004). Fas ligand as a tool for immunosuppression and generation of immune tolerance. Stem Cells, 22(6), 908-924.