Abstract
Farnysylated proteins are involved in adverse cell processes, and inhibition of farnesyl transferase offers an attractive target for oncology therapy. This discussion provides background information on the mechanism of action of farnesyl transferase inhibition and summarizes the available clinical data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S-37-S-40 |
| Journal | JNCCN Journal of the National Comprehensive Cancer Network |
| Volume | 3 |
| Issue number | SUPPL. 1 |
| State | Published - Nov 1 2005 |
Keywords
- Carcinoma
- Farnesyl transferase inhibition
- Hematologic malignancies
- Signal transduction
ASJC Scopus subject areas
- Oncology