Fanconi's anaemia and pregnancy

B. P. Alter, C. L. Frissora, D. S. Halperin, M. H. Freedman, U. Chitkara, E. Alvarez, L. Lynch, B. Adler-Brecher, A. D. Auerbach

Research output: Contribution to journalArticlepeer-review

Abstract

We have identified six new cases of Fanconi's anaemia (FA) who had pregnancies, and reviewed 11 others from the literature. At least 110 FA females have reached 16 years of age or more, of whom 15% became pregnant. There were a total of 26 pregnancies, resulting in 19 births and 18 surviving children. Anaemia and/or thrombocytopenia worsened during pregnancy in 10 patients, but five subsequently improved; seven had no haematological problems. Seven of the FA patients who had pregnancies died subsequently from cancer, and two from thrombocytopenic bleeding 3 and 20 years later. There were no peripartum deaths. Pregnancy in FA is clearly possible, with increased risks that are manageable from both the haematological and the obstetric aspects.

Original languageEnglish (US)
Pages (from-to)410-4518
Number of pages4109
JournalBritish Journal of Haematology
Volume77
Issue number3
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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