FANCD2 expression in advanced non-small-cell lung cancer and response to platinum-based chemotherapy

Miriam Ferrer, Simone W. Span, Barbara Vischioni, Joost J. Oudejans, Paul J. van Diest, Johan P. de Winter, Giuseppe Giaccone, Frank A.E. Kruyt

Research output: Contribution to journalArticle

Abstract

Fanconi's anemia (FA) is a genetically heterogeneous disease characterized by cancer susceptibility and hypersensitivity to cross-linking agents such as cisplatin. Recently, inactivation of the FA pathway has been proposed to contribute to genomic instability and an increased sensitivity to cisplatin-based therapy in a subset of ovarian tumors. Platinum-based chemotherapy constitutes standard systemic therapy for advanced non-small-cell lung cancer (NSCLC), but resistance to platinum chemotherapy is common. In this study, we evaluated the status of the FA pathway in tumor samples derived from patients with NSCLC in relation to their response to platinum-based chemotherapy. For this purpose, we assessed the expression of FANCD2 protein (a marker for FA pathway functioning) by immunohistochemistry in tumor specimens from 47 patients treated with platinum-based chemotherapy. FANCD2 expression could be detected in 32% of the cases (15 of 47). Expression of FANCD2 was not correlated with any patient or tumor characteristics, and FANCD2 expression was not a predictor of response to chemotherapy or patient survival. In conclusion, the activation status of the FA pathway had no value in predicting sensitivity to platinum-based chemotherapy in patients with advanced NSCLC.

Original languageEnglish (US)
Pages (from-to)250-254
Number of pages5
JournalClinical lung cancer
Volume6
Issue number4
DOIs
StatePublished - Jan 2005

Keywords

  • BCRA1
  • BCRA2
  • Chemotherapy resistance
  • Cisplatin
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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  • Cite this

    Ferrer, M., Span, S. W., Vischioni, B., Oudejans, J. J., van Diest, P. J., de Winter, J. P., Giaccone, G., & Kruyt, F. A. E. (2005). FANCD2 expression in advanced non-small-cell lung cancer and response to platinum-based chemotherapy. Clinical lung cancer, 6(4), 250-254. https://doi.org/10.3816/CLC.2005.n.005