Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA)

Arvind K. Pandey, Michael Blaha, Kavita Sharma, Juan Rivera, Matthew J. Budoff, Ron Blankstein, Mouaz Al-Mallah, Nathan D. Wong, Leslee Shaw, Jeffery Carr, Daniel O'Leary, Joao Lima, Moyses Szklo, Roger S Blumenthal, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Objective: We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). Background: MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. Methods: A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1±1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. Results: A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalAtherosclerosis
Volume232
Issue number2
DOIs
StatePublished - Feb 2014

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Coronary Disease
Disease Progression
Atherosclerosis
Coronary Vessels
Calcium
Incidence
Odds Ratio
Demography
Prospective Studies

Keywords

  • Coronary calcium
  • Family history
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Family history of coronary heart disease and the incidence and progression of coronary artery calcification : Multi-Ethnic Study of Atherosclerosis (MESA). / Pandey, Arvind K.; Blaha, Michael; Sharma, Kavita; Rivera, Juan; Budoff, Matthew J.; Blankstein, Ron; Al-Mallah, Mouaz; Wong, Nathan D.; Shaw, Leslee; Carr, Jeffery; O'Leary, Daniel; Lima, Joao; Szklo, Moyses; Blumenthal, Roger S; Nasir, Khurram.

In: Atherosclerosis, Vol. 232, No. 2, 02.2014, p. 369-376.

Research output: Contribution to journalArticle

Pandey, Arvind K. ; Blaha, Michael ; Sharma, Kavita ; Rivera, Juan ; Budoff, Matthew J. ; Blankstein, Ron ; Al-Mallah, Mouaz ; Wong, Nathan D. ; Shaw, Leslee ; Carr, Jeffery ; O'Leary, Daniel ; Lima, Joao ; Szklo, Moyses ; Blumenthal, Roger S ; Nasir, Khurram. / Family history of coronary heart disease and the incidence and progression of coronary artery calcification : Multi-Ethnic Study of Atherosclerosis (MESA). In: Atherosclerosis. 2014 ; Vol. 232, No. 2. pp. 369-376.
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AU - Pandey, Arvind K.

AU - Blaha, Michael

AU - Sharma, Kavita

AU - Rivera, Juan

AU - Budoff, Matthew J.

AU - Blankstein, Ron

AU - Al-Mallah, Mouaz

AU - Wong, Nathan D.

AU - Shaw, Leslee

AU - Carr, Jeffery

AU - O'Leary, Daniel

AU - Lima, Joao

AU - Szklo, Moyses

AU - Blumenthal, Roger S

AU - Nasir, Khurram

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AB - Objective: We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). Background: MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary heart disease (CHD) and CAC incidence or progression has not been described previously. Methods: A total of 5099 participants had detailed information about family history of CHD (late versus premature and parental versus sibling history). The mean time between CAC scans was 3.1±1.3 years. The association of late versus premature family history was assessed against CAC change using multivariate regression model adjusted for demographics and cardiac risk factors. Results: A family history of premature CHD was associated with an odds ratio (OR) of 1.55 (p

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