Family history of cancer and risk of pancreatic cancer

A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

Eric J. Jacobs, Stephen J. Chanock, Charles S. Fuchs, Andrea LaCroix, Robert R. McWilliams, Emily Steplowski, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, H. Bas Bueno-de-Mesquita, Myron Gross, Kathy Helzlsouer, Gloria Petersen, Wei Zheng, Ilir Agalliu, Naomi E. Allen, Laufey Amundadottir, Marie Christine Boutron-Ruault, Julie E. Buring, Federico Canzian, Sandra Clipp & 29 others Miren Dorronsoro, J. Michael Gaziano, Edward L. Giovannucci, Susan E. Hankinson, Patricia Hartge, Robert N. Hoover, David J. Hunter, Kevin B. Jacobs, Mazda Jenab, Peter Kraft, Charles Kooperberg, Shannon M. Lynch, Malin Sund, Julie B. Mendelsohn, Tracy Mouw, Christina C. Newton, Kim Overvad, Domenico Palli, Petra H M Peeters, Aleksandar Rajkovic, Xiao Ou Shu, Gilles Thomas, Geoffrey S. Tobias, Dimitrios Trichopoulos, Jarmo Virtamo, Jean Wactawski-Wende, Brian M. Wolpin, Kai Yu, Anne Zeleniuch-Jacquotte

Research output: Contribution to journalArticle

Abstract

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

Original languageEnglish (US)
Pages (from-to)1421-1428
Number of pages8
JournalInternational Journal of Cancer
Volume127
Issue number6
DOIs
StatePublished - Sep 1 2010

Fingerprint

Pancreatic Neoplasms
Neoplasms
Odds Ratio
Confidence Intervals
Prostatic Neoplasms
Ovarian Neoplasms
Case-Control Studies
Colorectal Neoplasms
Breast
Uncertainty
Siblings
China
Cohort Studies
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Jacobs, E. J., Chanock, S. J., Fuchs, C. S., LaCroix, A., McWilliams, R. R., Steplowski, E., ... Zeleniuch-Jacquotte, A. (2010). Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). International Journal of Cancer, 127(6), 1421-1428. https://doi.org/10.1002/ijc.25148

Family history of cancer and risk of pancreatic cancer : A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). / Jacobs, Eric J.; Chanock, Stephen J.; Fuchs, Charles S.; LaCroix, Andrea; McWilliams, Robert R.; Steplowski, Emily; Stolzenberg-Solomon, Rachael Z.; Arslan, Alan A.; Bas Bueno-de-Mesquita, H.; Gross, Myron; Helzlsouer, Kathy; Petersen, Gloria; Zheng, Wei; Agalliu, Ilir; Allen, Naomi E.; Amundadottir, Laufey; Boutron-Ruault, Marie Christine; Buring, Julie E.; Canzian, Federico; Clipp, Sandra; Dorronsoro, Miren; Gaziano, J. Michael; Giovannucci, Edward L.; Hankinson, Susan E.; Hartge, Patricia; Hoover, Robert N.; Hunter, David J.; Jacobs, Kevin B.; Jenab, Mazda; Kraft, Peter; Kooperberg, Charles; Lynch, Shannon M.; Sund, Malin; Mendelsohn, Julie B.; Mouw, Tracy; Newton, Christina C.; Overvad, Kim; Palli, Domenico; Peeters, Petra H M; Rajkovic, Aleksandar; Shu, Xiao Ou; Thomas, Gilles; Tobias, Geoffrey S.; Trichopoulos, Dimitrios; Virtamo, Jarmo; Wactawski-Wende, Jean; Wolpin, Brian M.; Yu, Kai; Zeleniuch-Jacquotte, Anne.

In: International Journal of Cancer, Vol. 127, No. 6, 01.09.2010, p. 1421-1428.

Research output: Contribution to journalArticle

Jacobs, EJ, Chanock, SJ, Fuchs, CS, LaCroix, A, McWilliams, RR, Steplowski, E, Stolzenberg-Solomon, RZ, Arslan, AA, Bas Bueno-de-Mesquita, H, Gross, M, Helzlsouer, K, Petersen, G, Zheng, W, Agalliu, I, Allen, NE, Amundadottir, L, Boutron-Ruault, MC, Buring, JE, Canzian, F, Clipp, S, Dorronsoro, M, Gaziano, JM, Giovannucci, EL, Hankinson, SE, Hartge, P, Hoover, RN, Hunter, DJ, Jacobs, KB, Jenab, M, Kraft, P, Kooperberg, C, Lynch, SM, Sund, M, Mendelsohn, JB, Mouw, T, Newton, CC, Overvad, K, Palli, D, Peeters, PHM, Rajkovic, A, Shu, XO, Thomas, G, Tobias, GS, Trichopoulos, D, Virtamo, J, Wactawski-Wende, J, Wolpin, BM, Yu, K & Zeleniuch-Jacquotte, A 2010, 'Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)', International Journal of Cancer, vol. 127, no. 6, pp. 1421-1428. https://doi.org/10.1002/ijc.25148
Jacobs, Eric J. ; Chanock, Stephen J. ; Fuchs, Charles S. ; LaCroix, Andrea ; McWilliams, Robert R. ; Steplowski, Emily ; Stolzenberg-Solomon, Rachael Z. ; Arslan, Alan A. ; Bas Bueno-de-Mesquita, H. ; Gross, Myron ; Helzlsouer, Kathy ; Petersen, Gloria ; Zheng, Wei ; Agalliu, Ilir ; Allen, Naomi E. ; Amundadottir, Laufey ; Boutron-Ruault, Marie Christine ; Buring, Julie E. ; Canzian, Federico ; Clipp, Sandra ; Dorronsoro, Miren ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Hankinson, Susan E. ; Hartge, Patricia ; Hoover, Robert N. ; Hunter, David J. ; Jacobs, Kevin B. ; Jenab, Mazda ; Kraft, Peter ; Kooperberg, Charles ; Lynch, Shannon M. ; Sund, Malin ; Mendelsohn, Julie B. ; Mouw, Tracy ; Newton, Christina C. ; Overvad, Kim ; Palli, Domenico ; Peeters, Petra H M ; Rajkovic, Aleksandar ; Shu, Xiao Ou ; Thomas, Gilles ; Tobias, Geoffrey S. ; Trichopoulos, Dimitrios ; Virtamo, Jarmo ; Wactawski-Wende, Jean ; Wolpin, Brian M. ; Yu, Kai ; Zeleniuch-Jacquotte, Anne. / Family history of cancer and risk of pancreatic cancer : A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). In: International Journal of Cancer. 2010 ; Vol. 127, No. 6. pp. 1421-1428.
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T2 - A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

AU - Jacobs, Eric J.

AU - Chanock, Stephen J.

AU - Fuchs, Charles S.

AU - LaCroix, Andrea

AU - McWilliams, Robert R.

AU - Steplowski, Emily

AU - Stolzenberg-Solomon, Rachael Z.

AU - Arslan, Alan A.

AU - Bas Bueno-de-Mesquita, H.

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AU - Petersen, Gloria

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AU - Boutron-Ruault, Marie Christine

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AU - Gaziano, J. Michael

AU - Giovannucci, Edward L.

AU - Hankinson, Susan E.

AU - Hartge, Patricia

AU - Hoover, Robert N.

AU - Hunter, David J.

AU - Jacobs, Kevin B.

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AU - Kraft, Peter

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AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

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