Family history influence on drug abuse severity and treatment outcome

Roy W. Pickens, Kenzie L. Preston, Donna R. Miles, Anne E. Gupman, Eric O. Johnson, David B. Newlin, Jim Soriano, Marianne B.M. Van Den Bree, Annie Umbricht

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Influence of parental alcohol/substance abuse on methadone maintenance therapy (MMT) outcome was examined in 164 DSM-III-R opioid dependent adults with no other current DSM Axis I disorder. Family history positive patients had more DSM-III-R opioid dependence symptoms and were more likely to be classified as severely dependent. However, when placed on identical daily doses of methadone (50 mg), they had lower rates of illicit opioid use but higher rates of cocaine use than family history negative patients. Both effects remained significant after adjusting for gender and race. These results suggest that common genetic factors may underlie both susceptibility to heroin dependence and response to therapeutic methadone treatment.

Original languageEnglish (US)
Pages (from-to)261-270
Number of pages10
JournalDrug and alcohol dependence
Volume61
Issue number3
DOIs
StatePublished - Feb 1 2001
Externally publishedYes

Keywords

  • Family history
  • Genetics
  • Heroin addiction
  • Maintenance
  • Methadone
  • Treatment outcome

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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