Family History and Risk of Ovarian Cancer

Edward L. Trimble, Vicki L. Seltzer

Research output: Contribution to journalLetter


Drs Foulkes and colleagues underscore a key point in the recommendations of the NIH Consensus Development Panel on Ovarian Cancer, namely, the importance of ascertaining family history to define a woman's inherited risk of ovarian, breast, colon, and other cancers. However, it is important to differentiate between those women whose pedigree fits one of the three major syndromes (site-specific ovarian cancer syndrome, breast-ovarian cancer syndrome, and Lynch II syndrome) and those in whom the appearance of ovarian cancer appears to be sporadic.1The vast majority (97%) of women with two or three relatives with ovarian cancer will not have a hereditary cancer syndrome.2,3Their lifetime probability of developing ovarian cancer appears to be about 7%. Those women whose family history is consistent with a hereditary cancer syndrome may have a lifetime risk of 40%, assuming an autosomal-dominant inheritance pattern with 80% penetrance.4The development of.

Original languageEnglish (US)
Number of pages1
JournalJAMA: The Journal of the American Medical Association
Issue number5
StatePublished - Aug 2 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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