Drs Foulkes and colleagues underscore a key point in the recommendations of the NIH Consensus Development Panel on Ovarian Cancer, namely, the importance of ascertaining family history to define a woman's inherited risk of ovarian, breast, colon, and other cancers. However, it is important to differentiate between those women whose pedigree fits one of the three major syndromes (site-specific ovarian cancer syndrome, breast-ovarian cancer syndrome, and Lynch II syndrome) and those in whom the appearance of ovarian cancer appears to be sporadic.1The vast majority (97%) of women with two or three relatives with ovarian cancer will not have a hereditary cancer syndrome.2,3Their lifetime probability of developing ovarian cancer appears to be about 7%. Those women whose family history is consistent with a hereditary cancer syndrome may have a lifetime risk of 40%, assuming an autosomal-dominant inheritance pattern with 80% penetrance.4The development of.
|Original language||English (US)|
|Number of pages||1|
|Journal||JAMA: The Journal of the American Medical Association|
|State||Published - Aug 2 1995|
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