Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder

Rami Abou Jamra, Johannes Schumacher, Astrid Golla, Carola Richter, Andreas C J Otte, Thomas G. Schulze, Stephanie Ohlraun, Wolfgang Maier, Marcella Rietschel, Sven Cichon, Peter Propping, Markus M. Nöthen

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for α-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The α 1c-adrenergic (ADRA-1C) receptor gene on 8p21, the α 2a-adrenergic (ADRA-2A) receptor gene on 10q25, and the α 2c-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5′UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5′UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes.

Original languageEnglish (US)
Pages (from-to)79-81
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume126 B
Issue number1
StatePublished - Apr 1 2004
Externally publishedYes

Keywords

  • Adrenergic receptor genes
  • Manic-depression
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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