Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder

Rami Abou Jamra; Johannes Schumacher; Astrid Golla; Carola Richter; Andreas C J Otte; Thomas G. Schulze; Stephanie Ohlraun; Wolfgang Maier; Marcella Rietschel; Sven Cichon; Peter Propping; Markus M. Nöthen

Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder

Rami Abou Jamra, Johannes Schumacher, Astrid Golla, Carola Richter, Andreas C J Otte, Thomas G. Schulze, Stephanie Ohlraun, Wolfgang Maier, Marcella Rietschel, Sven Cichon, Peter Propping, Markus M. Nöthen

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for α-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The α _1c-adrenergic (ADRA-1C) receptor gene on 8p21, the α _2a-adrenergic (ADRA-2A) receptor gene on 10q25, and the α _2c-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5′UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5′UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes.

Original language	English (US)
Pages (from-to)	79-81
Number of pages	3
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	126 B
Issue number	1
State	Published - Apr 1 2004
Externally published	Yes

Keywords

Adrenergic receptor genes
Manic-depression
Transmission disequilibrium test

ASJC Scopus subject areas

Genetics(clinical)
Neuropsychology and Physiological Psychology
General Neuroscience

Cite this

Jamra, R. A., Schumacher, J., Golla, A., Richter, C., Otte, A. C. J., Schulze, T. G., Ohlraun, S., Maier, W., Rietschel, M., Cichon, S., Propping, P., & Nöthen, M. M. (2004). Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics, 126 B(1), 79-81.

Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder. / Jamra, Rami Abou; Schumacher, Johannes; Golla, Astrid et al.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 126 B, No. 1, 01.04.2004, p. 79-81.

Research output: Contribution to journal › Article › peer-review

Jamra, RA, Schumacher, J, Golla, A, Richter, C, Otte, ACJ, Schulze, TG, Ohlraun, S, Maier, W, Rietschel, M, Cichon, S, Propping, P & Nöthen, MM 2004, 'Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 126 B, no. 1, pp. 79-81.

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abstract = "Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for α-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The α 1c-adrenergic (ADRA-1C) receptor gene on 8p21, the α 2a-adrenergic (ADRA-2A) receptor gene on 10q25, and the α 2c-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5′UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5′UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes.",

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Family-Based Association Studies of α-Adrenergic Receptor Genes in Chromosomal Regions with Linkage to Bipolar Affective Disorder

Abstract

Keywords

ASJC Scopus subject areas

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