Familial thyroid carcinoma: the road less traveled in thyroid pathology – an update

Virginia A. LiVolsi, Ezra Baraban, Zubair W. Baloch

Research output: Contribution to journalReview articlepeer-review

Abstract

This paper reviews the pathologic and clinicopathologic aspects of thyroid cancers and neoplasms which occur in familial settings. The data and details of C cell lesions are reviewed and a brief overview of the molecular-morphological correlations is presented. Familial tumors of follicular derivation are also described with a review of the many syndromes associated with these lesions. These tumors which may be papillary, follicular or Hurthle cell can occur solely as thyroid neoplasms without extrathyroidal manifestations or may accompany syndromes in which the extrathyroidal lesions are of primary prognostic importance (e.g. familial adenomatous polyposis). The pathologist may play a critical role in the identification of these syndromes by recognizing particular patterns of thyroid tumors (e.g. cribriform morular variant of papillary carcinoma). These issues are reviewed in this article.

Original languageEnglish (US)
Pages (from-to)366-377
Number of pages12
JournalDiagnostic Histopathology
Volume23
Issue number8
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • C cell tumors
  • familial tumors
  • syndromic neoplasms
  • thyroid cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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