Familial sneddon’s syndrome: Clinical, hematologic, and radiographic findings in two brothers

Allen D. Pettee, B. A. Wasserman, N. L. Adams, W. McMullen, H. R. Smith, S. L. Woods, O. D. Ratnoff

Research output: Contribution to journalArticlepeer-review

Abstract

We present the clinical, hematologic, and radiographic findings in two brothers with Sneddon’s syndrome (stroke and livedo reticularis) and antiphospholipid antibodies. Patient 1 had anticardiolipin antibody and patient 2 had lupus anticoagulant, which we detected only upon repeated blood testing. One should test for both anticardiolipin antibody and lupus anticoagulant and repeat the screenings before determining a Sneddon’s syndrome patient’s antiphospholipid antibody status. Both Sneddon’s syndrome and the primary antiphospholipid antibody syndrome are potentially familial causes of stroke. In familial cases, an inherited predisposition to antiphospholipid antibody production may be involved in disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalNeurology
Volume44
Issue number3
DOIs
StatePublished - Mar 1994
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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