Familial Nature of Alzheimer's Disease?

Barry Reisberg, Mony J. Deleon, Steven H. Ferris, John C.s. Breitner

Research output: Contribution to journalLetterpeer-review


To the Editor: The recent comment by Breitner and Folstein (July 19 issue)1 that the “90-year lifetime incidence of dementia in siblings or children of Alzheimer's disease probands with aphasia or apraxia approached 50 per cent” was not based on observation but on statistical projection. Accordingly, their report that this group comprises “78 per cent of Alzheimer's disease cases in nursing homes,” and presumably the majority of patients with Alzheimer's disease, may have prematurely alarmed relatives of patients with this disease. In a recent publication2 Breitner and Folstein reported that dementing disorder was present in 16 of 308 (5.19 per.

Original languageEnglish (US)
Pages (from-to)1318-1319
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - Nov 15 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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