Familial Mediterranean fever: Review of literature and report of two cases

Shama Khan, Manoochehr Karjoo, Sara Karjoo

Research output: Contribution to journalReview article

Abstract

Familial Mediterranean fever, an autosomal recessive disorder, is a member of the periodic fever syndromes, and considered to be the most common cause of recurrent febrile episodes in children. It is important to understand the disorder as familial Mediterranean fever falls on a spectrum of various presentations; the recurrent episodes of familial Mediterranean fever may be so severe that the quality of life may be affected in such patients. Therefore, physicians should not delay the evaluation in such cases and promptly initiate treatment to not only improve quality of life but to also avoid complications, such as amyloidosis. This study reports two different cases of familial Mediterranean fever, with varying clinical presentations, and established diagnosis via genetic testing as well as cessation of symptoms with a trial of therapy. Furthermore, this study discusses the various manifestations of familial Mediterranean fever, laboratory findings, and current therapies available for management.

Original languageEnglish (US)
Pages (from-to)6469-6484
Number of pages16
JournalInternational Journal of Pediatrics
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

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Familial Mediterranean Fever
Fever
Quality of Life
Genetic Testing
Amyloidosis
Therapeutics
Physicians

Keywords

  • Children
  • Familial Mediterranean fever
  • Hereditary periodic fever syndromes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Familial Mediterranean fever : Review of literature and report of two cases. / Khan, Shama; Karjoo, Manoochehr; Karjoo, Sara.

In: International Journal of Pediatrics, Vol. 5, No. 12, 01.12.2017, p. 6469-6484.

Research output: Contribution to journalReview article

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