Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25

J. Jen, C. J. Coulin, T. M. Bosley, M. A.M. Salih, C. Sabatti, S. F. Nelson, R. W. Baloh

Research output: Contribution to journalArticlepeer-review

Abstract

Horizontal gaze palsy with progressive scoliosis (HGPS) is a rare, autosomal recessive disorder characterized by a congenital absence of conjugate horizontal eye movement, with progressive scoliosis developing in childhood or adolescence. The authors identified two unrelated consanguineous families with HGPS. Genomewide homozygosity mapping and linkage analysis mapped the disease locus to a 30-cM interval on chromosome 11q23-25 (combined maximum multipoint lod score Z = 5.46).

Original languageEnglish (US)
Pages (from-to)432-435
Number of pages4
JournalNeurology
Volume59
Issue number3
DOIs
StatePublished - Aug 13 2002
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25'. Together they form a unique fingerprint.

Cite this