Familial Hodgkin's disease a clinical and laboratory investigation

Susan J. Robertson; James T. Lowman; Seymour Grufferman; Donna Kostyu; Charles M.Der Van Horst; Thomas J. Matthews; Michael J. Borowitz; Sandra H. Bigner

doi:10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V

Familial Hodgkin's disease a clinical and laboratory investigation

Susan J. Robertson, James T. Lowman, Seymour Grufferman, Donna Kostyu, Charles M.Der Van Horst, Thomas J. Matthews, Michael J. Borowitz, Sandra H. Bigner

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A three to sevenfold increased risk of Hodgkin's disease has been noted in families of patients. We report the first family in which all four of a four member sibship had Hodgkin's disease. In these four sibling cases, we were able to explore markers of infectious etiologic factors by measuring antibodies to Epstein Barr virus (EBV) and human T‐cell lymphotropic virus (HTLV), and possible genetic risk factors by human leukocyte antigen (HLA) typing and chromosome analysis. All three men were diagnosed within six months of their 30th birthday. HLA typing revealed that all four siblings share the DR5 antigen, and two siblings share HLA‐B27. Chromosome analysis on peripheral lymphocytes revealed no abnormalities. A detailed, structured interview failed to elicit evidence of unusual exposures. The EBV antibody titers are probably within the normal range and none of the family had antibodies to HTLV‐III. Observations on this family suggest that genetic factors play a greater role than environmental factors in the etiology of familial Hodgkin's disease.

Original language	English (US)
Pages (from-to)	1314-1319
Number of pages	6
Journal	Cancer
Volume	59
Issue number	7
DOIs	https://doi.org/10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V
State	Published - Apr 1 1987
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V

Cite this

@article{db5f86e703d047e98e9a34e6cdbaadbe,

title = "Familial Hodgkin's disease a clinical and laboratory investigation",

abstract = "A three to sevenfold increased risk of Hodgkin's disease has been noted in families of patients. We report the first family in which all four of a four member sibship had Hodgkin's disease. In these four sibling cases, we were able to explore markers of infectious etiologic factors by measuring antibodies to Epstein Barr virus (EBV) and human T‐cell lymphotropic virus (HTLV), and possible genetic risk factors by human leukocyte antigen (HLA) typing and chromosome analysis. All three men were diagnosed within six months of their 30th birthday. HLA typing revealed that all four siblings share the DR5 antigen, and two siblings share HLA‐B27. Chromosome analysis on peripheral lymphocytes revealed no abnormalities. A detailed, structured interview failed to elicit evidence of unusual exposures. The EBV antibody titers are probably within the normal range and none of the family had antibodies to HTLV‐III. Observations on this family suggest that genetic factors play a greater role than environmental factors in the etiology of familial Hodgkin's disease.",

author = "Robertson, {Susan J.} and Lowman, {James T.} and Seymour Grufferman and Donna Kostyu and {Van Horst}, {Charles M.Der} and Matthews, {Thomas J.} and Borowitz, {Michael J.} and Bigner, {Sandra H.}",

year = "1987",

month = apr,

day = "1",

doi = "10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V",

language = "English (US)",

volume = "59",

pages = "1314--1319",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "7",

}

TY - JOUR

T1 - Familial Hodgkin's disease a clinical and laboratory investigation

AU - Robertson, Susan J.

AU - Lowman, James T.

AU - Grufferman, Seymour

AU - Kostyu, Donna

AU - Van Horst, Charles M.Der

AU - Matthews, Thomas J.

AU - Borowitz, Michael J.

AU - Bigner, Sandra H.

PY - 1987/4/1

Y1 - 1987/4/1

N2 - A three to sevenfold increased risk of Hodgkin's disease has been noted in families of patients. We report the first family in which all four of a four member sibship had Hodgkin's disease. In these four sibling cases, we were able to explore markers of infectious etiologic factors by measuring antibodies to Epstein Barr virus (EBV) and human T‐cell lymphotropic virus (HTLV), and possible genetic risk factors by human leukocyte antigen (HLA) typing and chromosome analysis. All three men were diagnosed within six months of their 30th birthday. HLA typing revealed that all four siblings share the DR5 antigen, and two siblings share HLA‐B27. Chromosome analysis on peripheral lymphocytes revealed no abnormalities. A detailed, structured interview failed to elicit evidence of unusual exposures. The EBV antibody titers are probably within the normal range and none of the family had antibodies to HTLV‐III. Observations on this family suggest that genetic factors play a greater role than environmental factors in the etiology of familial Hodgkin's disease.

AB - A three to sevenfold increased risk of Hodgkin's disease has been noted in families of patients. We report the first family in which all four of a four member sibship had Hodgkin's disease. In these four sibling cases, we were able to explore markers of infectious etiologic factors by measuring antibodies to Epstein Barr virus (EBV) and human T‐cell lymphotropic virus (HTLV), and possible genetic risk factors by human leukocyte antigen (HLA) typing and chromosome analysis. All three men were diagnosed within six months of their 30th birthday. HLA typing revealed that all four siblings share the DR5 antigen, and two siblings share HLA‐B27. Chromosome analysis on peripheral lymphocytes revealed no abnormalities. A detailed, structured interview failed to elicit evidence of unusual exposures. The EBV antibody titers are probably within the normal range and none of the family had antibodies to HTLV‐III. Observations on this family suggest that genetic factors play a greater role than environmental factors in the etiology of familial Hodgkin's disease.

UR - http://www.scopus.com/inward/record.url?scp=0023097292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023097292&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V

DO - 10.1002/1097-0142(19870401)59:7<1314::AID-CNCR2820590714>3.0.CO;2-V

M3 - Article

C2 - 3028599

AN - SCOPUS:0023097292

SN - 0008-543X

VL - 59

SP - 1314

EP - 1319

JO - Cancer

JF - Cancer

IS - 7

ER -

Familial Hodgkin's disease a clinical and laboratory investigation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this