Familial clustering of malignant astrocytomas

Dominique Lossignol, Stuart A Grossman, Vivian R. Sheidler, Constance A. Griffin, Steven Piantadosi

Research output: Contribution to journalArticle

Abstract

Three of 32 consecutive patients with astrocytomas enrolled in an experimental chemotherapy protocol had at least one first degree relative with an astrocytoma. These patients did not have family members with an excess of malignancies, known exposure to a specific environmental factor, or a recognized neurocutaneous syndrome. In all three families, the illnesses temporally overlapped and the age of the patients affected in the second generation was less than those in the first generation. An estimation of the probability of developing astrocytomas in families with one affected individual strongly suggests a familial effect. Our observations, coupled with other cases reported in the literature, suggest that familial astrocytomas occur more frequently than is currently recognized. Identification and careful study of such families may provide important clues to the etiology of these malignancies.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalJournal of Neuro-Oncology
Volume9
Issue number2
DOIs
StatePublished - Oct 1990

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Astrocytoma
Cluster Analysis
Neurocutaneous Syndromes
Neoplasms
Drug Therapy

Keywords

  • astrocytoma
  • brain tumors
  • environmental
  • etiology
  • familial
  • genetic
  • glioblastoma
  • infectious
  • multiforme

ASJC Scopus subject areas

  • Neurology
  • Oncology
  • Clinical Neurology
  • Cancer Research
  • Neuroscience(all)

Cite this

Lossignol, D., Grossman, S. A., Sheidler, V. R., Griffin, C. A., & Piantadosi, S. (1990). Familial clustering of malignant astrocytomas. Journal of Neuro-Oncology, 9(2), 139-145. https://doi.org/10.1007/BF02427834

Familial clustering of malignant astrocytomas. / Lossignol, Dominique; Grossman, Stuart A; Sheidler, Vivian R.; Griffin, Constance A.; Piantadosi, Steven.

In: Journal of Neuro-Oncology, Vol. 9, No. 2, 10.1990, p. 139-145.

Research output: Contribution to journalArticle

Lossignol, D, Grossman, SA, Sheidler, VR, Griffin, CA & Piantadosi, S 1990, 'Familial clustering of malignant astrocytomas', Journal of Neuro-Oncology, vol. 9, no. 2, pp. 139-145. https://doi.org/10.1007/BF02427834
Lossignol D, Grossman SA, Sheidler VR, Griffin CA, Piantadosi S. Familial clustering of malignant astrocytomas. Journal of Neuro-Oncology. 1990 Oct;9(2):139-145. https://doi.org/10.1007/BF02427834
Lossignol, Dominique ; Grossman, Stuart A ; Sheidler, Vivian R. ; Griffin, Constance A. ; Piantadosi, Steven. / Familial clustering of malignant astrocytomas. In: Journal of Neuro-Oncology. 1990 ; Vol. 9, No. 2. pp. 139-145.
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