Familial aggregation of vibrio cholerae-associated infection in Matlab, Bangladesh

Kazi Mizanur Rahman, Priya Duggal, Jason B. Harris, Sajal Kumar Saha, Peter Kim Streatfield, Edward T. Ryan, Stephen B. Calderwood, Firdausi Qadri, Mohammad Yunus, Regina C. LaRocque

Research output: Contribution to journalArticle

Abstract

Vibrio cholerae is a major cause of diarrhoeal illness in endemic regions, such as Bangladesh. Understanding the factors that determine an individual's susceptibility to infection due to V. cholerae may lead to improved prevention and control strategies. Increasing evidence suggests that human genetic factors affect the severity of V. cholerae-associated infection. This study, therefore, sought to characterize the heritable component of susceptibility to infection due to V. cholerae using the Matlab Health and Demographic Surveillance System database of the International Centre for Diarrhoeal Disease Research, Bangladesh. In total, 144 pedigrees that included a cholera patient and 341 pedigrees without a cholera patient were evaluated during 1 January-31 December 1992. The odds of the sibling of a patient being admitted with cholera were 7.67 times the odds of the sibling of an unaffected individual being admitted with cholera [95% confidence interval (CI) 2.40-24.5, p

Original languageEnglish (US)
Pages (from-to)733-738
Number of pages6
JournalJournal of Health, Population and Nutrition
Volume27
Issue number6
StatePublished - Dec 2009
Externally publishedYes

Fingerprint

cholera
Vibrio cholerae
Bangladesh
Cholera
Pedigree
Infection
infection
pedigree
Siblings
Medical Genetics
confidence interval
diarrhea
demographic statistics
Demography
Databases
Confidence Intervals
monitoring
Health
Research

Keywords

  • Bangladesh
  • Case-control studies
  • Cholera
  • Familial aggregation
  • Risk factors
  • Vibrio cholerae

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Food Science
  • Health, Toxicology and Mutagenesis

Cite this

Rahman, K. M., Duggal, P., Harris, J. B., Saha, S. K., Streatfield, P. K., Ryan, E. T., ... LaRocque, R. C. (2009). Familial aggregation of vibrio cholerae-associated infection in Matlab, Bangladesh. Journal of Health, Population and Nutrition, 27(6), 733-738.

Familial aggregation of vibrio cholerae-associated infection in Matlab, Bangladesh. / Rahman, Kazi Mizanur; Duggal, Priya; Harris, Jason B.; Saha, Sajal Kumar; Streatfield, Peter Kim; Ryan, Edward T.; Calderwood, Stephen B.; Qadri, Firdausi; Yunus, Mohammad; LaRocque, Regina C.

In: Journal of Health, Population and Nutrition, Vol. 27, No. 6, 12.2009, p. 733-738.

Research output: Contribution to journalArticle

Rahman, KM, Duggal, P, Harris, JB, Saha, SK, Streatfield, PK, Ryan, ET, Calderwood, SB, Qadri, F, Yunus, M & LaRocque, RC 2009, 'Familial aggregation of vibrio cholerae-associated infection in Matlab, Bangladesh', Journal of Health, Population and Nutrition, vol. 27, no. 6, pp. 733-738.
Rahman, Kazi Mizanur ; Duggal, Priya ; Harris, Jason B. ; Saha, Sajal Kumar ; Streatfield, Peter Kim ; Ryan, Edward T. ; Calderwood, Stephen B. ; Qadri, Firdausi ; Yunus, Mohammad ; LaRocque, Regina C. / Familial aggregation of vibrio cholerae-associated infection in Matlab, Bangladesh. In: Journal of Health, Population and Nutrition. 2009 ; Vol. 27, No. 6. pp. 733-738.
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