TY - JOUR
T1 - Familial aggregation of sarcoidosis
T2 - A Case-Control Etiologic Study of Sarcoidosis (ACCESS)
AU - Rybicki, Benjamin A.
AU - Iannuzzi, Michael C.
AU - Frederick, Margaret M.
AU - Thompson, Bruce W.
AU - Rossman, Milton D.
AU - Bresnitz, Eddy A.
AU - Terrin, Michael L.
AU - Moller, David R.
AU - Barnard, Juliana
AU - Baughman, Robert P.
AU - Depalo, Louis
AU - Hunninghake, Gary
AU - Johns, Carol
AU - Judson, Marc A.
AU - Knatterud, Genell L.
AU - McLennan, Geoffrey
AU - Newman, Lee S.
AU - Rabin, David L.
AU - Rose, Cecile
AU - Teirstein, Alvin S.
AU - Weinberger, Steven E.
AU - Yeager, Henry
AU - Cherniack, Reuben
PY - 2001/12/1
Y1 - 2001/12/1
N2 - Despite reports of familial clustering of sarcoidosis, little empirical evidence exists that disease risk in family members of sarcoidosis cases is greater than that in the general population. To address this question, we estimated sarcoidosis familial relative risk using data on disease occurrence in 10,862 first- and 17,047 second-degree relatives of 706 age, sex, race, and geographically matched cases and controls who participated in the multicenter ACCESS (A Case-Control Etiology Study of Sarcoidosis) study from 1996 to 1999. Familial relative risk estimates were calculated using a logistic regression technique that accounted for the dependence between relatives. Sibs had the highest relative risk (odds ratio [OR] = 5.8; 95% confidence interval [CI] = 2.1-15.9), followed by avuncular relationships (OR = 5.7; 95% CI = 1.6-20.7), grandparents (OR = 5.2; 95% CI = 1.5-18.0), and then parents (OR = 3.8; 95% CI = 1.2-11.3). In a multivariate model fit to the parents and sibs data, the familial relative risk adjusted for age, sex, relative class, and shared environment was 4.7 (95% CI = 2.3-9.7). White cases had a markedly higher familial relative risk compared with African-American cases (18.0 versus 2.8; p = 0.098). In summary, a significant elevated risk of sarcoidosis was observed among first- and second-degree relatives of sarcoidosis cases compared with relatives of matched control subjects.
AB - Despite reports of familial clustering of sarcoidosis, little empirical evidence exists that disease risk in family members of sarcoidosis cases is greater than that in the general population. To address this question, we estimated sarcoidosis familial relative risk using data on disease occurrence in 10,862 first- and 17,047 second-degree relatives of 706 age, sex, race, and geographically matched cases and controls who participated in the multicenter ACCESS (A Case-Control Etiology Study of Sarcoidosis) study from 1996 to 1999. Familial relative risk estimates were calculated using a logistic regression technique that accounted for the dependence between relatives. Sibs had the highest relative risk (odds ratio [OR] = 5.8; 95% confidence interval [CI] = 2.1-15.9), followed by avuncular relationships (OR = 5.7; 95% CI = 1.6-20.7), grandparents (OR = 5.2; 95% CI = 1.5-18.0), and then parents (OR = 3.8; 95% CI = 1.2-11.3). In a multivariate model fit to the parents and sibs data, the familial relative risk adjusted for age, sex, relative class, and shared environment was 4.7 (95% CI = 2.3-9.7). White cases had a markedly higher familial relative risk compared with African-American cases (18.0 versus 2.8; p = 0.098). In summary, a significant elevated risk of sarcoidosis was observed among first- and second-degree relatives of sarcoidosis cases compared with relatives of matched control subjects.
KW - Blacks
KW - Family
KW - Risk
KW - Whites
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U2 - 10.1164/ajrccm.164.11.2106001
DO - 10.1164/ajrccm.164.11.2106001
M3 - Article
C2 - 11739139
AN - SCOPUS:20244381341
SN - 1073-449X
VL - 164
SP - 2085
EP - 2091
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 11
ER -