Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees

Francis M. Mondimore, Peter P. Zandi, Dean F. MacKinnon, Melvin G. McInnis, Erin B. Miller, Raymond P. Crowe, William A. Scheftner, Diana H. Marta, Myrna M. Weissman, Douglas F. Levinson, Kathleen P. Murphy-Ebenez, J. Raymond DePaulo, James B. Potash

Research output: Contribution to journalArticle

Abstract

Objective: The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder. Method: A measure of lifetime chronicity of depressive symptoms (substantial mood symptoms most or all of the time) was tested for familial aggregation in 638 pedigrees from the Genetics of Recurrent Early-Onset Depression (GenRED) project. Results: In subjects with chronic depression, the mean age at illness onset was lower and rates of attempted suicide, panic disorder, and substance abuse were higher than among those with nonchronic depression. Chronicity was assessed in 37.8% of affected first-degree relatives of probands with chronic depression and in 20.2% of relatives of probands with nonchronic depression. Analysis using the generalized estimating equation model yielded an odds ratio of 2.52 (SE=0.39, z= 6.02, p

Original languageEnglish (US)
Pages (from-to)1554-1560
Number of pages7
JournalAmerican Journal of Psychiatry
Volume163
Issue number9
DOIs
StatePublished - Sep 2006

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Pedigree
Depression
Attempted Suicide
Panic Disorder
Major Depressive Disorder
Age of Onset
Substance-Related Disorders
Chronic Disease
Odds Ratio

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees. / Mondimore, Francis M.; Zandi, Peter P.; MacKinnon, Dean F.; McInnis, Melvin G.; Miller, Erin B.; Crowe, Raymond P.; Scheftner, William A.; Marta, Diana H.; Weissman, Myrna M.; Levinson, Douglas F.; Murphy-Ebenez, Kathleen P.; DePaulo, J. Raymond; Potash, James B.

In: American Journal of Psychiatry, Vol. 163, No. 9, 09.2006, p. 1554-1560.

Research output: Contribution to journalArticle

Mondimore, FM, Zandi, PP, MacKinnon, DF, McInnis, MG, Miller, EB, Crowe, RP, Scheftner, WA, Marta, DH, Weissman, MM, Levinson, DF, Murphy-Ebenez, KP, DePaulo, JR & Potash, JB 2006, 'Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees', American Journal of Psychiatry, vol. 163, no. 9, pp. 1554-1560. https://doi.org/10.1176/appi.ajp.163.9.1554
Mondimore, Francis M. ; Zandi, Peter P. ; MacKinnon, Dean F. ; McInnis, Melvin G. ; Miller, Erin B. ; Crowe, Raymond P. ; Scheftner, William A. ; Marta, Diana H. ; Weissman, Myrna M. ; Levinson, Douglas F. ; Murphy-Ebenez, Kathleen P. ; DePaulo, J. Raymond ; Potash, James B. / Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees. In: American Journal of Psychiatry. 2006 ; Vol. 163, No. 9. pp. 1554-1560.
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