TY - JOUR
T1 - Familial aggregation of forearm bone mineral density in Chinese
AU - Hong, Xiumei
AU - Niu, Tianhua
AU - Chen, Changzhong
AU - Wang, Binyan
AU - Venners, Scott A.
AU - Fang, Zhian
AU - Xu, Xiping
N1 - Funding Information:
Acknowledgments We wish to acknowledge the assistance and cooperation of the faculty and staff of the Harvard School of Public health, the Anqing Medical University, Anqing Public Health Bureau and Anqing Hospital. Drs. Changzhong Chen and Binyan Wang were supported in part by Fogarty International Center Training Grant TW00828.
PY - 2007/5
Y1 - 2007/5
N2 - Osteoporosis is a major public health concern and its prevalence can be predicted based on forearm bone mineral density (BMD). This study is to investigate the familial aggregation of forearm BMD in a population-based, cross-sectional study in Anhui, China. Information on sociodemographic and environmental variables was obtained from 1,636 subjects from 409 nuclear families (including mother, father, and their first two children) by a standardized questionnaire. The forearm BMD was measured by peripheral dual-energy X-ray absorptiometry (pDXA). Using generalized additive models with a sequential adjustment for covariates, it was clearly indicated that the forearm BMD of the mother, the father, and the first sibling each had a significant and independent relation to the forearm BMD of the second sibling. Furthermore, using multiple logistic regression, the second sibling had an odds ratio (OR) of 5.3 (95%CI: 2.0-14.5) of having an extremely low (bottom 10th percentile) proximal forearm BMD and an OR of 4.3 (95%CI: 1.6-12.0) of having an extremely low distal forearm BMD when the parental mean forearm BMD was low and the first sibling's forearm BMD was low. Our findings showing strong familial aggregation of both proximal and distal forearm BMD values suggest that genetic factors play a significant role in determining both traits.
AB - Osteoporosis is a major public health concern and its prevalence can be predicted based on forearm bone mineral density (BMD). This study is to investigate the familial aggregation of forearm BMD in a population-based, cross-sectional study in Anhui, China. Information on sociodemographic and environmental variables was obtained from 1,636 subjects from 409 nuclear families (including mother, father, and their first two children) by a standardized questionnaire. The forearm BMD was measured by peripheral dual-energy X-ray absorptiometry (pDXA). Using generalized additive models with a sequential adjustment for covariates, it was clearly indicated that the forearm BMD of the mother, the father, and the first sibling each had a significant and independent relation to the forearm BMD of the second sibling. Furthermore, using multiple logistic regression, the second sibling had an odds ratio (OR) of 5.3 (95%CI: 2.0-14.5) of having an extremely low (bottom 10th percentile) proximal forearm BMD and an OR of 4.3 (95%CI: 1.6-12.0) of having an extremely low distal forearm BMD when the parental mean forearm BMD was low and the first sibling's forearm BMD was low. Our findings showing strong familial aggregation of both proximal and distal forearm BMD values suggest that genetic factors play a significant role in determining both traits.
KW - Bone mineral density
KW - Familial aggregation
KW - Regression model
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U2 - 10.1007/s10654-007-9117-2
DO - 10.1007/s10654-007-9117-2
M3 - Article
C2 - 17484033
AN - SCOPUS:34250003970
SN - 0393-2990
VL - 22
SP - 335
EP - 341
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 5
ER -