Familial aggregation of fainting in a case - Control study of neurally mediated hypotension patients who present with unexplained chronic fatigue

Katherine E. Lucas, Haroutune K. Armenian, Gloria M. Petersen, Peter Rowe

Research output: Contribution to journalArticle

Abstract

Aims: We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting. Methods and results: A nested case-control study of Gulf War veterans gathered fainting histories directly from 197 first-degree relatives of 16 fatigued NMH cases, 26 fatigued controls, and 17 healthy controls. NMH status was determined by tilt testing. Female relatives of fatigued controls reported more fainting than female relatives of cases (P <0.01); there were no significant differences in the frequency of fainting in male relatives by case or control status, or in either gender by age at first faint or by familial relationship to the proband. The odds of NMH patients giving any family history of fainting were 0.56 (95% CI 0.15, 2.07). Recurrence risks calculated using lifetime prevalences of fainting in male military personnel of similar age to our participants were low (1.5-1.7) and did not differ by case or control status. Conclusion: Family history of fainting is not a risk factor for adult-onset NMH in fatigued veterans. Our findings may differ from other studies of familial aggregation in NMH because of study methods or because NMH-fatiguers may differ from NMH-fainters.

Original languageEnglish (US)
Pages (from-to)846-851
Number of pages6
JournalEuropace
Volume8
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Syncope
Hypotension
Fatigue
Case-Control Studies
Veterans
Gulf War
Military Personnel
Recurrence

Keywords

  • Fatigue
  • Gulf War syndrome
  • Heredity
  • Vasovagal syncope

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Familial aggregation of fainting in a case - Control study of neurally mediated hypotension patients who present with unexplained chronic fatigue. / Lucas, Katherine E.; Armenian, Haroutune K.; Petersen, Gloria M.; Rowe, Peter.

In: Europace, Vol. 8, No. 10, 10.2006, p. 846-851.

Research output: Contribution to journalArticle

Lucas, Katherine E. ; Armenian, Haroutune K. ; Petersen, Gloria M. ; Rowe, Peter. / Familial aggregation of fainting in a case - Control study of neurally mediated hypotension patients who present with unexplained chronic fatigue. In: Europace. 2006 ; Vol. 8, No. 10. pp. 846-851.
@article{ac5cf00abab849c8a77f468a7810dd4e,
title = "Familial aggregation of fainting in a case - Control study of neurally mediated hypotension patients who present with unexplained chronic fatigue",
abstract = "Aims: We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting. Methods and results: A nested case-control study of Gulf War veterans gathered fainting histories directly from 197 first-degree relatives of 16 fatigued NMH cases, 26 fatigued controls, and 17 healthy controls. NMH status was determined by tilt testing. Female relatives of fatigued controls reported more fainting than female relatives of cases (P <0.01); there were no significant differences in the frequency of fainting in male relatives by case or control status, or in either gender by age at first faint or by familial relationship to the proband. The odds of NMH patients giving any family history of fainting were 0.56 (95{\%} CI 0.15, 2.07). Recurrence risks calculated using lifetime prevalences of fainting in male military personnel of similar age to our participants were low (1.5-1.7) and did not differ by case or control status. Conclusion: Family history of fainting is not a risk factor for adult-onset NMH in fatigued veterans. Our findings may differ from other studies of familial aggregation in NMH because of study methods or because NMH-fatiguers may differ from NMH-fainters.",
keywords = "Fatigue, Gulf War syndrome, Heredity, Vasovagal syncope",
author = "Lucas, {Katherine E.} and Armenian, {Haroutune K.} and Petersen, {Gloria M.} and Peter Rowe",
year = "2006",
month = "10",
doi = "10.1093/europace/eul092",
language = "English (US)",
volume = "8",
pages = "846--851",
journal = "Europace",
issn = "1099-5129",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Familial aggregation of fainting in a case - Control study of neurally mediated hypotension patients who present with unexplained chronic fatigue

AU - Lucas, Katherine E.

AU - Armenian, Haroutune K.

AU - Petersen, Gloria M.

AU - Rowe, Peter

PY - 2006/10

Y1 - 2006/10

N2 - Aims: We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting. Methods and results: A nested case-control study of Gulf War veterans gathered fainting histories directly from 197 first-degree relatives of 16 fatigued NMH cases, 26 fatigued controls, and 17 healthy controls. NMH status was determined by tilt testing. Female relatives of fatigued controls reported more fainting than female relatives of cases (P <0.01); there were no significant differences in the frequency of fainting in male relatives by case or control status, or in either gender by age at first faint or by familial relationship to the proband. The odds of NMH patients giving any family history of fainting were 0.56 (95% CI 0.15, 2.07). Recurrence risks calculated using lifetime prevalences of fainting in male military personnel of similar age to our participants were low (1.5-1.7) and did not differ by case or control status. Conclusion: Family history of fainting is not a risk factor for adult-onset NMH in fatigued veterans. Our findings may differ from other studies of familial aggregation in NMH because of study methods or because NMH-fatiguers may differ from NMH-fainters.

AB - Aims: We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting. Methods and results: A nested case-control study of Gulf War veterans gathered fainting histories directly from 197 first-degree relatives of 16 fatigued NMH cases, 26 fatigued controls, and 17 healthy controls. NMH status was determined by tilt testing. Female relatives of fatigued controls reported more fainting than female relatives of cases (P <0.01); there were no significant differences in the frequency of fainting in male relatives by case or control status, or in either gender by age at first faint or by familial relationship to the proband. The odds of NMH patients giving any family history of fainting were 0.56 (95% CI 0.15, 2.07). Recurrence risks calculated using lifetime prevalences of fainting in male military personnel of similar age to our participants were low (1.5-1.7) and did not differ by case or control status. Conclusion: Family history of fainting is not a risk factor for adult-onset NMH in fatigued veterans. Our findings may differ from other studies of familial aggregation in NMH because of study methods or because NMH-fatiguers may differ from NMH-fainters.

KW - Fatigue

KW - Gulf War syndrome

KW - Heredity

KW - Vasovagal syncope

UR - http://www.scopus.com/inward/record.url?scp=33749676032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749676032&partnerID=8YFLogxK

U2 - 10.1093/europace/eul092

DO - 10.1093/europace/eul092

M3 - Article

C2 - 16920765

AN - SCOPUS:33749676032

VL - 8

SP - 846

EP - 851

JO - Europace

JF - Europace

SN - 1099-5129

IS - 10

ER -