TY - JOUR
T1 - Familial aggregation and early expression of hyperapobetalipoproteinemia
AU - Sniderman, Allan
AU - Teng, Babie
AU - Genest, Jacques
AU - Cianflone, Katherine
AU - Wacholder, Sholom
AU - Kwiterovich, Peter
N1 - Funding Information:
From the Cardiovascular Research Unit, Department of Medicine, Royal Victoria Hospital; The Department of Epidemiology, McGill University, Montreal, Canada; Departments of Pediatrics and Medicine, Lipid Research-Atherosclerosis Unit, The Johns Hopkins University School of Medicine, Baltimore, Maryland. This study was supported by March of Dimes Defect Foundation: Contract No. l-HVI-2158; Medical Research Council of Canada MA-5480; National Heart, Lung, and Blood Institute Grant CRC-RR-52, Pediatric Clinical Research Center, Program of the Division of Research Resources, and Chant HL-18574, National Institutes of Health.
PY - 1985/2/1
Y1 - 1985/2/1
N2 - Family history is an important predictor of coronary risk. However, this relation, in large part, is not explained by the known risk factors such as systemic hypertension or hyperlipidemia. In the present study, plasma lipid, lipoprotein lipid, and plasma lowdensity lipoprotein (LDL) apoB levels were measured in 66 offspring (myocardial infarction [MI] offspring) of 24 families in which an index parent had premature coronary artery disease and hyperapobetalipoproteinemia. These results were compared to those obtained in 207 control children and young adults. Univariate analysis revealed that plasma LDL apoB and all other lipid and lipoprotein levels except high-density lipoprotein cholesterol were significantly higher in the MI offspring. Multivariate analysis showed plasma LDL apoB and LDL cholesterol best differentiated the MI offspring from control children and young adults. Of the 66 children, 22 had hyperapobetalipoproteinemia, of whom only 7 had clearly abnormal LDL cholesterol or plasma triglyceride levels. Thus, a substantial portion of children born to a parent with premature coronary artery disease and hyperapobetalipoproteinemia have the same disorder of lipoprotein metabolism.
AB - Family history is an important predictor of coronary risk. However, this relation, in large part, is not explained by the known risk factors such as systemic hypertension or hyperlipidemia. In the present study, plasma lipid, lipoprotein lipid, and plasma lowdensity lipoprotein (LDL) apoB levels were measured in 66 offspring (myocardial infarction [MI] offspring) of 24 families in which an index parent had premature coronary artery disease and hyperapobetalipoproteinemia. These results were compared to those obtained in 207 control children and young adults. Univariate analysis revealed that plasma LDL apoB and all other lipid and lipoprotein levels except high-density lipoprotein cholesterol were significantly higher in the MI offspring. Multivariate analysis showed plasma LDL apoB and LDL cholesterol best differentiated the MI offspring from control children and young adults. Of the 66 children, 22 had hyperapobetalipoproteinemia, of whom only 7 had clearly abnormal LDL cholesterol or plasma triglyceride levels. Thus, a substantial portion of children born to a parent with premature coronary artery disease and hyperapobetalipoproteinemia have the same disorder of lipoprotein metabolism.
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U2 - 10.1016/0002-9149(85)90363-7
DO - 10.1016/0002-9149(85)90363-7
M3 - Article
C2 - 3969864
AN - SCOPUS:0021931391
SN - 0002-9149
VL - 55
SP - 291
EP - 295
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 4
ER -