Familial aggregation and early expression of hyperapobetalipoproteinemia

Allan Sniderman, Babie Teng, Jacques Genest, Katherine Cianflone, Sholom Wacholder, Peter Kwiterovich

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Family history is an important predictor of coronary risk. However, this relation, in large part, is not explained by the known risk factors such as systemic hypertension or hyperlipidemia. In the present study, plasma lipid, lipoprotein lipid, and plasma lowdensity lipoprotein (LDL) apoB levels were measured in 66 offspring (myocardial infarction [MI] offspring) of 24 families in which an index parent had premature coronary artery disease and hyperapobetalipoproteinemia. These results were compared to those obtained in 207 control children and young adults. Univariate analysis revealed that plasma LDL apoB and all other lipid and lipoprotein levels except high-density lipoprotein cholesterol were significantly higher in the MI offspring. Multivariate analysis showed plasma LDL apoB and LDL cholesterol best differentiated the MI offspring from control children and young adults. Of the 66 children, 22 had hyperapobetalipoproteinemia, of whom only 7 had clearly abnormal LDL cholesterol or plasma triglyceride levels. Thus, a substantial portion of children born to a parent with premature coronary artery disease and hyperapobetalipoproteinemia have the same disorder of lipoprotein metabolism.

Original languageEnglish (US)
Pages (from-to)291-295
Number of pages5
JournalThe American journal of cardiology
Issue number4
StatePublished - Feb 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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