Familial abnormalities of lymphocyte function in a large Sjogren's syndrome kindred

Douglas Jabs, F. C. Arnett, W. B. Bias, M. G. Beale

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Abstract

A large kindred (32 members), whose proband had primary Sjoegren's syndrome, was investigated to ascertain whether abnormalities of lymphocyte function were present in family members of patients with Sjoegren's syndrome. Ten members of the kindred with autoimmune diseases, 17 blood relatives, 5 spouses, and 32 matched controls were studied. Concanavalin A induced suppression of pokeweed mitogen stimulated immunoglobulin synthesis was decreased in patients and blood relatives both with and without autoimmune diseases. Elevations of the mean T4/T8 ratio, due to decreased numbers of suppressor/cytotoxic lymphocytes, were present in both the disease group and the blood relatives. These abnormalities occurred independently of HLA and were not necessarily associated with autoantibodies.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalJournal of Rheumatology
Volume13
Issue number2
Publication statusPublished - Dec 1 1986

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ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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