False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography

Masafumi Kidoh; Zeyang Shen; Yuki Suzuki; Luisa Ciuffo; Hiroshi Ashikaga; Shiu-Kai Fung; Yoshito Otake; Stefan L. Zimmerman; Joao A.C. Lima; Takahiro Higuchi; Okkyun Lee; Yoshinobu Sato; Lewis C. Becker; Elliot K. Fishman; Katsuyuki Taguchi

doi:10.1117/12.2250257

False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography

Masafumi Kidoh, Zeyang Shen, Yuki Suzuki, Luisa Ciuffo, Hiroshi Ashikaga, Shiu-Kai Fung, Yoshito Otake, Stefan L. Zimmerman, Joao A.C. Lima, Takahiro Higuchi, Okkyun Lee, Yoshinobu Sato, Lewis C. Becker, Elliot K. Fishman, Katsuyuki Taguchi

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have developed a digitally synthesized patient which we call "Zach" (Zero millisecond Adjustable Clinical Heart) phantom, which allows for an access to the ground truth and assessment of image-based cardiac functional analysis (CFA) using CT images with clinically realistic settings. The study using Zach phantom revealed a major problem with image-based CFA: "False dyssynchrony." Even though the true motion of wall segments is in synchrony, it may appear to be dyssynchrony with the reconstructed cardiac CT images. It is attributed to how cardiac images are reconstructed and how wall locations are updated over cardiac phases. The presence and the degree of false dyssynchrony may vary from scan-to-scan, which could degrade the accuracy and the repeatability (or precision) of image-based CT-CFA exams.

Original language	English (US)
Title of host publication	Medical Imaging 2017
Subtitle of host publication	Physics of Medical Imaging
Editors	Taly Gilat Schmidt, Joseph Y. Lo, Thomas G. Flohr
Publisher	SPIE
ISBN (Electronic)	9781510607095
DOIs	https://doi.org/10.1117/12.2250257
State	Published - 2017
Event	Medical Imaging 2017: Physics of Medical Imaging - Orlando, United States Duration: Feb 13 2017 → Feb 16 2017

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10132
ISSN (Print)	1605-7422

Other

Other	Medical Imaging 2017: Physics of Medical Imaging
Country/Territory	United States
City	Orlando
Period	2/13/17 → 2/16/17

Keywords

Cardiac function analysis
Computed tomography
Dyssynchrony

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2250257

Cite this

Kidoh, M., Shen, Z., Suzuki, Y., Ciuffo, L., Ashikaga, H., Fung, S.-K., Otake, Y., Zimmerman, S. L., Lima, J. A. C., Higuchi, T., Lee, O., Sato, Y., Becker, L. C., Fishman, E. K., & Taguchi, K. (2017). False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography. In T. G. Schmidt, J. Y. Lo, & T. G. Flohr (Eds.), Medical Imaging 2017: Physics of Medical Imaging Article 101321U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10132). SPIE. https://doi.org/10.1117/12.2250257

False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography. / Kidoh, Masafumi; Shen, Zeyang; Suzuki, Yuki et al.
Medical Imaging 2017: Physics of Medical Imaging. ed. / Taly Gilat Schmidt; Joseph Y. Lo; Thomas G. Flohr. SPIE, 2017. 101321U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10132).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kidoh, M, Shen, Z, Suzuki, Y, Ciuffo, L, Ashikaga, H, Fung, S-K, Otake, Y, Zimmerman, SL , Lima, JAC, Higuchi, T, Lee, O, Sato, Y, Becker, LC, Fishman, EK & Taguchi, K 2017, False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography. in TG Schmidt, JY Lo & TG Flohr (eds), Medical Imaging 2017: Physics of Medical Imaging., 101321U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10132, SPIE, Medical Imaging 2017: Physics of Medical Imaging, Orlando, United States, 2/13/17. https://doi.org/10.1117/12.2250257

Kidoh M, Shen Z, Suzuki Y, Ciuffo L, Ashikaga H, Fung SK et al. False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography. In Schmidt TG, Lo JY, Flohr TG, editors, Medical Imaging 2017: Physics of Medical Imaging. SPIE. 2017. 101321U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2250257

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keywords = "Cardiac function analysis, Computed tomography, Dyssynchrony",

author = "Masafumi Kidoh and Zeyang Shen and Yuki Suzuki and Luisa Ciuffo and Hiroshi Ashikaga and Shiu-Kai Fung and Yoshito Otake and Zimmerman, {Stefan L.} and Lima, {Joao A.C.} and Takahiro Higuchi and Okkyun Lee and Yoshinobu Sato and Becker, {Lewis C.} and Fishman, {Elliot K.} and Katsuyuki Taguchi",

note = "Funding Information: This work was supported in part by NIH research grant No. R56 HL 125680 and Japan Government Grant MEXT/JSPS KAKENHI #26108004. Publisher Copyright: {\textcopyright} 2017 SPIE.; Medical Imaging 2017: Physics of Medical Imaging ; Conference date: 13-02-2017 Through 16-02-2017",

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language = "English (US)",

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AU - Fung, Shiu-Kai

AU - Otake, Yoshito

AU - Zimmerman, Stefan L.

AU - Lima, Joao A.C.

AU - Higuchi, Takahiro

AU - Lee, Okkyun

AU - Sato, Yoshinobu

AU - Becker, Lewis C.

AU - Fishman, Elliot K.

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N2 - We have developed a digitally synthesized patient which we call "Zach" (Zero millisecond Adjustable Clinical Heart) phantom, which allows for an access to the ground truth and assessment of image-based cardiac functional analysis (CFA) using CT images with clinically realistic settings. The study using Zach phantom revealed a major problem with image-based CFA: "False dyssynchrony." Even though the true motion of wall segments is in synchrony, it may appear to be dyssynchrony with the reconstructed cardiac CT images. It is attributed to how cardiac images are reconstructed and how wall locations are updated over cardiac phases. The presence and the degree of false dyssynchrony may vary from scan-to-scan, which could degrade the accuracy and the repeatability (or precision) of image-based CT-CFA exams.

AB - We have developed a digitally synthesized patient which we call "Zach" (Zero millisecond Adjustable Clinical Heart) phantom, which allows for an access to the ground truth and assessment of image-based cardiac functional analysis (CFA) using CT images with clinically realistic settings. The study using Zach phantom revealed a major problem with image-based CFA: "False dyssynchrony." Even though the true motion of wall segments is in synchrony, it may appear to be dyssynchrony with the reconstructed cardiac CT images. It is attributed to how cardiac images are reconstructed and how wall locations are updated over cardiac phases. The presence and the degree of false dyssynchrony may vary from scan-to-scan, which could degrade the accuracy and the repeatability (or precision) of image-based CT-CFA exams.

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False dyssynchrony: Problem with image-based cardiac functional analysis using x-ray computed tomography

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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