Failure to restore the Vγ2-Jγ1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)

Andrew M. Hebbeler, Nadia Propp, Cristiana Cairo, Haishan Li, Jean Saville Cummings, Lisa P. Jacobson, Joseph B. Margolick, C. David Pauza

Research output: Contribution to journalArticle

Abstract

Gammadelta (γδ) T cells expressing the Vγ2-Jγ1.2Vδ2 (Vγ9-JPVδ2, alternate nomenclature) T cell receptor (TCR) constitute the major peripheral blood population of γδ T cells in adult humans and are specifically depleted during human immunodeficiency virus (HIV) disease. Vγ2-Jγ1.2Vδ2 T cells provide a convenient model for assessing the impact of antiretroviral therapy on cell populations that are not susceptible to direct infection because they do not express CD4 and depletion occurs by indirect mechanisms. We obtained longitudinal PBMC samples from 16 HIV-infected individuals who enrolled in the Multicenter AIDS Cohort Study (MACS) and were starting highly active antiretroviral therapy (HAART). Vγ2-Jγ1.2Vδ2 T cells were depleted in these individuals as a result of HIV infection. Despite evidence for clinical benefits of HAART, the Vγ2-Jγ1.2Vδ2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV.

Original languageEnglish (US)
Pages (from-to)349-357
Number of pages9
JournalClinical Immunology
Volume128
Issue number3
DOIs
StatePublished - Sep 1 2008

Keywords

  • Antiretroviral therapy
  • Gamma/delta
  • HIV/AIDS
  • Immune reconstitution
  • Repertoire
  • T cell receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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