Failure to detect Chlamydia pneumoniae in coronary atheromas of patients undergoing atherectomy

Steven M. Weiss, Patricia M. Roblin, Charlotte A. Gaydos, Peter Cummings, Dorothy L. Patton, Nancy Schulhoff, Jacob Shani, Robert Frankel, Keith Penney, Thomas C. Quinn, Margaret R. Hammerschlag, Julius Schachter

Research output: Contribution to journalArticlepeer-review

Abstract

To further investigate a proposed relationship between Chlamydia pneumoniae and coronary heart disease, coronary atheromas were collected from patients undergoing percutaneous atherectomy. Fifty-eight atheroma specimens were examined by culture and polymerase chain reaction (PCR) and 22 by electron microscopy. All were negative for C. pneumoniae, except a single specimen that was PCR-positive. These results differ from studies in other populations, in which this organism was identified by nonculture methods within coronary atheromas obtained at autopsy. Anti-C. pneumoniae antibody titers from 65 of the patients were compared with those of 28 asymptomatic controls. IgG titers were higher in controls than in patients. There is no evidence that C. pneumoniae exists within atheromas in this study population, nor does seroprevalence correlate with the presence of coronary disease in these patients.

Original languageEnglish (US)
Pages (from-to)957-962
Number of pages6
JournalJournal of Infectious Diseases
Volume173
Issue number4
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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