Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit

J. G S Breed, A. N E Zimmerman, J. A M A Dormans, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, vitamin E has been proposed to protect against Adriamycin-induced cardiotoxicity. We studied contractile decline and ultramicroscopic alterations of the heart of rabbits chronically treated with Adriamycin up to a cumulative dose of 400 mg/sq m. High doses of vitamin E did not protect against the Adriamycin-induced development of severe contractile decline as evaluated by means of measurement of the interval-force relationship curve. Light and electron microscopic analysis did not show any signs of protection against Adriamycin-induced morphological alterations. Biochemical and hematological alterations caused by the antineoplastic agent were similar in both Adriamycin-treated animal groups. Coadministration of vitamin E did result in an increased life span. This study indicates that vitamin E does not protect against the development of cardiomyopathy and contractile decline after chronic exposure to Adriamycin.

Original languageEnglish (US)
Pages (from-to)2033-2038
Number of pages6
JournalCancer Research
Volume40
Issue number6
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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