Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis

Bruce M. Greene, Neil R Miller, Turner E. Bynum

Research output: Contribution to journalArticle

Abstract

Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. Progression of neurosyphilis despite 7.2 million units of penicillin G benzathine occurred in the case reported here, with subsequent resolution following high-dose intravenous aqueous penicillin therapy. This and other recent reports support the conclusion that neurosyphilis should be treated with higher amounts of penicillin than is provided by the benzathine regimens.

Original languageEnglish (US)
Pages (from-to)1117-1118
Number of pages2
JournalArchives of Internal Medicine
Volume140
Issue number8
DOIs
StatePublished - 1980

Fingerprint

Penicillin G Benzathine
Neurosyphilis
Penicillins
Syphilis
Nervous System
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis. / Greene, Bruce M.; Miller, Neil R; Bynum, Turner E.

In: Archives of Internal Medicine, Vol. 140, No. 8, 1980, p. 1117-1118.

Research output: Contribution to journalArticle

Greene, Bruce M. ; Miller, Neil R ; Bynum, Turner E. / Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis. In: Archives of Internal Medicine. 1980 ; Vol. 140, No. 8. pp. 1117-1118.
@article{15a11bcc1ad44a94a0bb48818787f60d,
title = "Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis",
abstract = "Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. Progression of neurosyphilis despite 7.2 million units of penicillin G benzathine occurred in the case reported here, with subsequent resolution following high-dose intravenous aqueous penicillin therapy. This and other recent reports support the conclusion that neurosyphilis should be treated with higher amounts of penicillin than is provided by the benzathine regimens.",
author = "Greene, {Bruce M.} and Miller, {Neil R} and Bynum, {Turner E.}",
year = "1980",
doi = "10.1001/archinte.1980.00330190129043",
language = "English (US)",
volume = "140",
pages = "1117--1118",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Failure of Penicillin G Benzathine in the Treatment of Neurosyphilis

AU - Greene, Bruce M.

AU - Miller, Neil R

AU - Bynum, Turner E.

PY - 1980

Y1 - 1980

N2 - Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. Progression of neurosyphilis despite 7.2 million units of penicillin G benzathine occurred in the case reported here, with subsequent resolution following high-dose intravenous aqueous penicillin therapy. This and other recent reports support the conclusion that neurosyphilis should be treated with higher amounts of penicillin than is provided by the benzathine regimens.

AB - Although penicillin remains highly effective in syphilis, important questions exist regarding the optimal regimen for syphilitic involvement of the nervous system. Progression of neurosyphilis despite 7.2 million units of penicillin G benzathine occurred in the case reported here, with subsequent resolution following high-dose intravenous aqueous penicillin therapy. This and other recent reports support the conclusion that neurosyphilis should be treated with higher amounts of penicillin than is provided by the benzathine regimens.

UR - http://www.scopus.com/inward/record.url?scp=0018945895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018945895&partnerID=8YFLogxK

U2 - 10.1001/archinte.1980.00330190129043

DO - 10.1001/archinte.1980.00330190129043

M3 - Article

VL - 140

SP - 1117

EP - 1118

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 8

ER -