Failure of papaverine to alter l-dopa-influenced gh and prl secretion

David S. Cooper; Laurence S. Jacobs

doi:10.1210/jcem-44-3-585

Failure of papaverine to alter l-dopa-influenced gh and prl secretion

David S. Cooper, Laurence S. Jacobs

Research output: Contribution to journal › Article › peer-review

Abstract

Papaverine150 mg BID for 2 weeks, a dose which produced marked clinical impairment in Parkinsonian patients taking L-Dopa, failed to alter L-Dopa-stimulated GH secretion or L-Dopainhibited PRL secretion in 6 normal volunteers. Failure to demonstrate an inhibitory effect of papaverine on dopaminergic hypothalamic-pituitary systems, despite its inhibition of striatal dopaminergic pathways, may imply qualitative or quantitative functional differences between hypothalamic and striatal dopaminergic systems.

Original language	English (US)
Pages (from-to)	585-587
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	44
Issue number	3
DOIs	https://doi.org/10.1210/jcem-44-3-585
State	Published - Mar 1977
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-44-3-585

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abstract = "Papaverine150 mg BID for 2 weeks, a dose which produced marked clinical impairment in Parkinsonian patients taking L-Dopa, failed to alter L-Dopa-stimulated GH secretion or L-Dopainhibited PRL secretion in 6 normal volunteers. Failure to demonstrate an inhibitory effect of papaverine on dopaminergic hypothalamic-pituitary systems, despite its inhibition of striatal dopaminergic pathways, may imply qualitative or quantitative functional differences between hypothalamic and striatal dopaminergic systems.",

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Failure of papaverine to alter l-dopa-influenced gh and prl secretion

Abstract

ASJC Scopus subject areas

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