Failure of methylprednisolone to protect myocardial function or prevent myocardial edema following ischemic cardiac arrest

Richard A. Goldman, Hartzell V. Schaff, John T. Flaherty, Bernadine H. Bulkley, Robert K. Brawley, James S. Donahoo, Vincent L. Gott

Research output: Contribution to journalArticlepeer-review

Abstract

The results of the present study suggest that, in hearts subjected to hypothermic global ischemia and reperfusion, pretreatment with methylprednisolone: (1) does not reduce indexes of myocardial ischemia during the period of cross clamp, (2) does not improve myocardial contractility during the reperfusion period despite significantly increasing coronary blood flow, (3) does not afford additional protection to myocardial structure by either light or electron microscopy, (4) does result in increased myocardial edema, and (5) does result in an increase in isovolumic end-diastolic pressure, which is most likely the result of decreasing left ventricular cavity size and not a result of an increase in left ventricular wall stiffness.

Original languageEnglish (US)
Pages (from-to)477-487
Number of pages11
JournalJournal of Surgical Research
Volume24
Issue number6
DOIs
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Surgery

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