Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity

Roni Nielsen, Helene Nørrelund, Ulla Kampmann, Won Yong Kim, Steffen Ringgaard, Michael Schar, Niels Møller, Hans Erik Bøtker, Henrik Wiggers

Research output: Contribution to journalArticle

Abstract

Background-Circulating lipid levels and myocardial lipid content (MyLC) is increased in type 2 diabetes mellitus. This may cause a state of lipotoxicity that compromises left ventricular function and aggravate heart failure. We investigated the relationship among circulating lipid levels, MyLC, and cardiac function together with the acute cardiac effects of high as opposed to low circulating free fatty acid (FFA) and triglyceride levels in patients with type 2 diabetes mellitus and heart failure. Methods and Results-Eighteen patients underwent 8-hour intralipid/heparin-infusion (high FFA) and hyperinsulinemiceuglycemic clamping (low FFA) in a randomized crossover-designed study. We applied magnetic resonance proton spectroscopy to measure MyLC. Cardiac function was assessed by advanced echocardiography, cardiopulmonary exercise, and MRI. MyLC correlated positively with circulating triglyceride (r=0.47; r2=0.22; P=0.003) and FFA (r=0.45; r2=0.20; P=0.001) levels and inversely with left ventricular ejection fraction (r=-0.54; r2=0.29; P=0.004). Circulating FFA concentrations differed between study arms (0.05±0.04 mmol/L [low FFA] versus 1.04±0.27 mmol/L [high FFA]; P

Original languageEnglish (US)
Pages (from-to)845-852
Number of pages8
JournalCirculation: Heart Failure
Volume6
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

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Nonesterified Fatty Acids
Type 2 Diabetes Mellitus
Lipids
Triglycerides
Heart Failure
Left Ventricular Function
Constriction
Stroke Volume
Cross-Over Studies
Echocardiography
Heparin
Exercise

Keywords

  • Echocardiography
  • Heart failure
  • Magnetic resonance spectroscopy
  • Ventricular function, left

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity. / Nielsen, Roni; Nørrelund, Helene; Kampmann, Ulla; Kim, Won Yong; Ringgaard, Steffen; Schar, Michael; Møller, Niels; Bøtker, Hans Erik; Wiggers, Henrik.

In: Circulation: Heart Failure, Vol. 6, No. 4, 07.2013, p. 845-852.

Research output: Contribution to journalArticle

Nielsen, Roni ; Nørrelund, Helene ; Kampmann, Ulla ; Kim, Won Yong ; Ringgaard, Steffen ; Schar, Michael ; Møller, Niels ; Bøtker, Hans Erik ; Wiggers, Henrik. / Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity. In: Circulation: Heart Failure. 2013 ; Vol. 6, No. 4. pp. 845-852.
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