Failed organ preservation strategy for adult laryngeal embryonal rhabdomyosarcoma

Jonathon Russell, Peter C. Revenaugh, G. Thomas Budd, John Greskovich, Joseph Scharpf

Research output: Contribution to journalArticle

Abstract

Purpose To present a case of embryonal rhabdomyosarcoma of the intrinsic laryngeal musculature and discuss the treatment of this rare tumor. Methods and materials A 45 year-old male presented with an eleven month history of hoarseness. A mass of the posterior glottis was noted on fiberoptic laryngoscopy. Computed tomography indicated a 1.5 × 2.5 cm laryngeal mass without cartilage involvement. Direct laryngoscopy and biopsy were consistent with embryonal rhabdomyosarcoma involving the interarytenoid muscle. A multidisciplinary tumor board recommended multimodality therapy including total laryngectomy. His case was reviewed along with the available English language literature. Results The patient refused surgery, and he qualified for a pediatric rhabdomyosarcoma treatment protocol with induction chemotherapy followed by combined chemoradiation. There was no noted response and the patient was taken off protocol to increase the radiation dose without chemotherapy. Fifteen weeks following radiation, a repeat biopsy revealed viable tumor. The patient elected further experimental chemotherapy at an outside hospital. The patient currently is alive at 34 months post-treatment with suspected persistent disease and continues to refuse surgery. Conclusions Embryonal rhabdomyosarcoma involving the larynx is an extremely rare tumor usually seen in children. There have been few previous adult cases reported and treatment options are not well described. We present a case of chemoradiation failure in an adult with embryonal rhabdomyosarcoma refusing surgical intervention. Although pediatric tumors can be effectively treated with organ preservation strategies, adult tumors may have a poorer response. Based upon our experience and existing literature regarding adult embryonal rhabdomyosarcoma of the larynx, multimodality therapy including surgical resection should be the treatment of choice.

Original languageEnglish (US)
Pages (from-to)277-279
Number of pages3
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume36
Issue number2
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

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Embryonal Rhabdomyosarcoma
Organ Preservation
Neoplasms
Laryngoscopy
Larynx
Therapeutics
Radiation
Pediatrics
Glottis
Biopsy
Drug Therapy
Hoarseness
Laryngectomy
Induction Chemotherapy
Rhabdomyosarcoma
Clinical Protocols
Cartilage
Language
Tomography
Muscles

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Failed organ preservation strategy for adult laryngeal embryonal rhabdomyosarcoma. / Russell, Jonathon; Revenaugh, Peter C.; Budd, G. Thomas; Greskovich, John; Scharpf, Joseph.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 36, No. 2, 01.03.2015, p. 277-279.

Research output: Contribution to journalArticle

Russell, Jonathon ; Revenaugh, Peter C. ; Budd, G. Thomas ; Greskovich, John ; Scharpf, Joseph. / Failed organ preservation strategy for adult laryngeal embryonal rhabdomyosarcoma. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2015 ; Vol. 36, No. 2. pp. 277-279.
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