Factors underlying prefrontal and insula structural alterations in smokers

Xiaochu Zhang, Betty Jo Salmeron, Thomas J. Ross, Xiujuan Geng, Yihong Yang, Elliot A. Stein

Research output: Contribution to journalArticle

Abstract

Based upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalNeuroImage
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Zhang, X., Salmeron, B. J., Ross, T. J., Geng, X., Yang, Y., & Stein, E. A. (2011). Factors underlying prefrontal and insula structural alterations in smokers. NeuroImage, 54(1), 42-48. https://doi.org/10.1016/j.neuroimage.2010.08.008