Factors related to hospitalization in elderly manic patients with early and late-onset bipolar disorder

Research output: Contribution to journalArticle


Objective: To identify factors contributing to relapse and hospitalization in elderly patients with bipolar disorder. Method: Retrospective chart review surveyed consecutive patients over age 65 admitted to the Johns Hopkins Hospital for a manic episode over a five year period (n = 73). Factors precipitating index admission were compared in patients with early-onset bipolar disorder (<or = age 45, n = 38) and late-onset bipolar disorder (>age 45, n = 35). Results: The distribution of ages of onset of bipolar disorder was most consistent with a bimodal pattern with a cut-point at age 45. Early-onset patients were more likely to have been aggressive and threatening prior to admission (p = 0.014) compared to late-onset patients and were more likely to have been brought to the emergency room on emergency petition for evaluation (p = 0.028). Early-onset patients were also more likely to have been non-adherent with prescribed psychiatric medication (p = 0.032). Conclusions: Relapse and rehospitalization were common among elderly manic patients with early-onset and late-onset bipolar disorder. Strategies which improve medication adherence are needed to help prevent recurring hospitalization.

Original languageEnglish (US)
Pages (from-to)1060-1064
Number of pages5
JournalInternational journal of geriatric psychiatry
Issue number11
StatePublished - Nov 1 2006


  • Bipolar disorder
  • Elderly
  • Hospitalization
  • Mania
  • Relapse

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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