Factors predicting non-completion of tuberculosis treatment among HIV- infected patients in Barcelona (1987-1996)

Hernando Galdós Tangüis, J. A. Caylà, P. García De Olalla, J. M. Jansà, M. T. Brugal

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine the predictive factors of noncompletion of tuberculosis (TB) treatment among patients infected with the human immunodeficiency virus (HIV). DESIGN: Between 1987 and 1996, 2201 HIV- infected TB patients were detected by the Barcelona Tuberculosis Prevention and Control Programme. Patients who completed treatment were compared to those who abandoned. Bivariate analysis was made by χ2 test to compare qualitative variables. Associations were measured by means of odds ratios (OR) with 95% confidence intervals (CI). Variables showing a statistically significant association were analysed at multivariate level by means of a logistic regression model. RESULTS: Treatment was carried to completion by 1065 patients (48.4%), 289 (13.1%) abandoned, 648 (29.5%) died during treatment, and 142 (6.5%) moved out of the city. Final outcome could not be established in 57 (2.5%). Intravenous drug users (IDU) represented 76.2% of patients. The rate of non-completion between 1987 and 1992 was 26.3% and for 1993-1996 it was 15.1%, a decrease of 42.6%. Living in neighbourhoods of a low socio-economic level (OR 1.61; 95%CI 1.222.13), homelessness (OR 3.56; 95%CI 2.01-6.31), history of TB (OR 1.61; 95%CI 1.12-2.33), and having presented with a current TB episode in 1987-1992 (OR 1.42; 95%CI 1.01-2.00), were risk factors for abandoning TB treatment. CONCLUSIONS: Social and health factors together influence non-completion of TB treatment in HIV-infected patients, while health interventions can improve treatment completion.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume4
Issue number1
StatePublished - Jan 1 2000

Keywords

  • Completion
  • HIV
  • Treatment
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Factors predicting non-completion of tuberculosis treatment among HIV- infected patients in Barcelona (1987-1996)'. Together they form a unique fingerprint.

  • Cite this

    Galdós Tangüis, H., Caylà, J. A., García De Olalla, P., Jansà, J. M., & Brugal, M. T. (2000). Factors predicting non-completion of tuberculosis treatment among HIV- infected patients in Barcelona (1987-1996). International Journal of Tuberculosis and Lung Disease, 4(1), 55-60.