Factors influencing the spread of pertussis in households: A prospective study, catalonia and navarre, Spain, 2012 to 2013

Pere Godoy, M. García-Cenoz, D. Toledo, G. Carmona, J. A. Caylà, M. Alsedà, J. Àlvarez, I. Barrabeig, N. Camps, P. Plans, M. Company, J. Castilla, M. Sala-Farré, C. Muñoz-Almagro, C. Rius, Domínguez, Transmission of Pertussis in Households Working Group

Research output: Contribution to journalArticle

Abstract

We aimed to investigate transmission rates of pertussis in household contacts of cases and factors associated with transmission. A prospective epidemiological study was conducted in 2012 and 2013 to determine the incidence of pertussis among household contacts of reported cases in Catalonia and Navarre, Spain. An epidemiological survey was completed for each case and contact, who were followed for 28 days to determine the source of infection (primary case) and detect the occurrence of secondary cases. Odds ratios (ORs) were used to estimate the effectiveness of vaccination and chemoprophylaxis in preventing new cases, using the formula (1 − OR) × 100. For the 688 primary cases, a total of 2,852 contacts were recorded. The household transmission rate was 16.1% (459/2,852) and rose according to the age (> 18 years) and lack of immunisation of the primary cases, and also the age (0–18 years), family relationship (siblings and children), lack of vaccination and chemoprophylaxis of contacts. Pertussis vaccine effectiveness in preventing new cases was 65.0% (95% confidence interval (CI): 11.6 to 86.2) for full vaccination (≥ 4 doses) and 59.7% (95% CI: −6.8 to 84.8) for incomplete vaccination (< 4 doses). The effectiveness of chemoprophylaxis was 62.1% (95% CI: 40.3 to 75.9). To reduce household transmission, contacts should be investigated to detect further cases and to administer chemoprophylaxis. The current vaccination status of cases and contacts can reduce household transmission.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalEurosurveillance
Volume21
Issue number45
DOIs
StatePublished - Nov 10 2016
Externally publishedYes

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Whooping Cough
Spain
Chemoprevention
Vaccination
Prospective Studies
Confidence Intervals
Odds Ratio
Pertussis Vaccine
Family Relations
Siblings
Epidemiologic Studies
Immunization
Incidence
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Godoy, P., García-Cenoz, M., Toledo, D., Carmona, G., Caylà, J. A., Alsedà, M., ... Transmission of Pertussis in Households Working Group (2016). Factors influencing the spread of pertussis in households: A prospective study, catalonia and navarre, Spain, 2012 to 2013. Eurosurveillance, 21(45), 24-33. https://doi.org/10.2807/1560-7917.ES.2016.21.45.30393

Factors influencing the spread of pertussis in households : A prospective study, catalonia and navarre, Spain, 2012 to 2013. / Godoy, Pere; García-Cenoz, M.; Toledo, D.; Carmona, G.; Caylà, J. A.; Alsedà, M.; Àlvarez, J.; Barrabeig, I.; Camps, N.; Plans, P.; Company, M.; Castilla, J.; Sala-Farré, M.; Muñoz-Almagro, C.; Rius, C.; Domínguez; Transmission of Pertussis in Households Working Group.

In: Eurosurveillance, Vol. 21, No. 45, 10.11.2016, p. 24-33.

Research output: Contribution to journalArticle

Godoy, P, García-Cenoz, M, Toledo, D, Carmona, G, Caylà, JA, Alsedà, M, Àlvarez, J, Barrabeig, I, Camps, N, Plans, P, Company, M, Castilla, J, Sala-Farré, M, Muñoz-Almagro, C, Rius, C, Domínguez & Transmission of Pertussis in Households Working Group 2016, 'Factors influencing the spread of pertussis in households: A prospective study, catalonia and navarre, Spain, 2012 to 2013', Eurosurveillance, vol. 21, no. 45, pp. 24-33. https://doi.org/10.2807/1560-7917.ES.2016.21.45.30393
Godoy, Pere ; García-Cenoz, M. ; Toledo, D. ; Carmona, G. ; Caylà, J. A. ; Alsedà, M. ; Àlvarez, J. ; Barrabeig, I. ; Camps, N. ; Plans, P. ; Company, M. ; Castilla, J. ; Sala-Farré, M. ; Muñoz-Almagro, C. ; Rius, C. ; Domínguez ; Transmission of Pertussis in Households Working Group. / Factors influencing the spread of pertussis in households : A prospective study, catalonia and navarre, Spain, 2012 to 2013. In: Eurosurveillance. 2016 ; Vol. 21, No. 45. pp. 24-33.
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