Factors influencing the immune enhancement of intrapulmonary bactericidal mechanisms

G. J. Jakab

Research output: Contribution to journalArticle

Abstract

The effect of specific immunization on the antibacterial defense mechanisms of the murine lung was assessed against Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus aureus (Smith), Serratia marcescens, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa. Immunization by aerosol inhalation significantly enhanced the intrapulmonary killing of Pseudomonas aeruginosa and Proteus mirabilis but not the remaining organisms. With P. mirabilis, systemic immunization induced higher titers of specific serum agglutinins as compared with local respiratory tract immunization; however, local immunization was more effective in enhancing pulmonary bactericidal activity than was parenteral vaccination. Passive immunity against P. mirabilis or aerogenic challenge with preopsonized P. mirabilis significantly enhanced intrapulmonary killing of the homologous organism. With S. aureus, pulmonary bactericidal activity was not accelerated by aerosol challenge with the preopsonized organism, nor was it accelerated in passively immunized mice. These data demonstrate that the immune enhancement of pulmonary bactericidal activity is governed by the bacterium used for challenge and the route of immunization. The results further demonstrate that with P. mirabilis, antibody mediated mechanisms are involved in the immune enhancement of pulmonary bactericidal activity.

Original languageEnglish (US)
Pages (from-to)389-398
Number of pages10
JournalInfection and Immunity
Volume14
Issue number2
StatePublished - 1976
Externally publishedYes

Fingerprint

Proteus mirabilis
Immunologic Factors
Immunization
Lung
Staphylococcus aureus
Aerosols
Pseudomonas aeruginosa
Serratia marcescens
Agglutinins
Klebsiella pneumoniae
Streptococcus pneumoniae
Respiratory System
Inhalation
Immunity
Vaccination
Bacteria
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Factors influencing the immune enhancement of intrapulmonary bactericidal mechanisms. / Jakab, G. J.

In: Infection and Immunity, Vol. 14, No. 2, 1976, p. 389-398.

Research output: Contribution to journalArticle

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