Abstract
Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.
Original language | English (US) |
---|---|
Pages (from-to) | 624-627 |
Number of pages | 4 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 13 |
Issue number | 4 |
DOIs | |
State | Published - 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases