Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett, A. E. Jennings

Research output: Contribution to journal › Article

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume13
Issue number4
StatePublished - 1978
Externally publishedYes

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Nocardia
Sulfamethoxazole Drug Combination Trimethoprim
Trimethoprim

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole. / Bennett, J. E.; Jennings, A. E.

In: Antimicrobial Agents and Chemotherapy, Vol. 13, No. 4, 1978, p. 624-627.

Research output: Contribution to journal › Article

Bennett, JE & Jennings, AE 1978, 'Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole', Antimicrobial Agents and Chemotherapy, vol. 13, no. 4, pp. 624-627.
Bennett JE, Jennings AE. Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole. Antimicrobial Agents and Chemotherapy. 1978;13(4):624-627.
Bennett, J. E. ; Jennings, A. E. / Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole. In: Antimicrobial Agents and Chemotherapy. 1978 ; Vol. 13, No. 4. pp. 624-627.
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