Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett; A. E. Jennings

doi:10.1128/AAC.13.4.624

Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett, A. E. Jennings

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

Original language	English (US)
Pages (from-to)	624-627
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	13
Issue number	4
DOIs	https://doi.org/10.1128/AAC.13.4.624
State	Published - 1978

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.",

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Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

Abstract

ASJC Scopus subject areas

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