Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett, A. E. Jennings

Research output: Contribution to journalArticlepeer-review

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume13
Issue number4
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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