Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett; A. E. Jennings

doi:10.1128/AAC.13.4.624

Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

J. E. Bennett, A. E. Jennings

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

Original language	English (US)
Pages (from-to)	624-627
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	13
Issue number	4
DOIs	https://doi.org/10.1128/AAC.13.4.624
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.",

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Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole

Abstract

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