Abstract
Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 624-627 |
| Number of pages | 4 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1978 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Cite this
Bennett, J. E., & Jennings, A. E. (1978). Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole. Antimicrobial agents and chemotherapy, 13(4), 624-627. https://doi.org/10.1128/AAC.13.4.624