Factors influencing central lamina cribrosa depth: A multicenter study

Haomin Luo, Hongli Yang, Stuart K. Gardiner, Christy Hardin, Glen P. Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A. Girkin, Jeffrey M. Liebmann, Christian Y. Mardin, Harry A Quigley, Alexander F. Scheuerle, Brad Fortune, Balwantray C. Chauhan, Claude F. Burgoyne

Research output: Contribution to journalArticle

Abstract

PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.

Original languageEnglish (US)
Pages (from-to)2357-2370
Number of pages14
JournalInvestigative Ophthalmology and Visual Science
Volume59
Issue number6
DOIs
StatePublished - May 1 2018

Fingerprint

Bruch Membrane
Multicenter Studies
Sclera
Optic Disk
Optical Coherence Tomography
Hispanic Americans
Glaucoma
Healthy Volunteers
Demography

Keywords

  • Bruch’s membrane
  • Glaucoma
  • Laminar depth
  • Optic nerve head
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Luo, H., Yang, H., Gardiner, S. K., Hardin, C., Sharpe, G. P., Caprioli, J., ... Burgoyne, C. F. (2018). Factors influencing central lamina cribrosa depth: A multicenter study. Investigative Ophthalmology and Visual Science, 59(6), 2357-2370. https://doi.org/10.1167/iovs.17-23456

Factors influencing central lamina cribrosa depth : A multicenter study. / Luo, Haomin; Yang, Hongli; Gardiner, Stuart K.; Hardin, Christy; Sharpe, Glen P.; Caprioli, Joseph; Demirel, Shaban; Girkin, Christopher A.; Liebmann, Jeffrey M.; Mardin, Christian Y.; Quigley, Harry A; Scheuerle, Alexander F.; Fortune, Brad; Chauhan, Balwantray C.; Burgoyne, Claude F.

In: Investigative Ophthalmology and Visual Science, Vol. 59, No. 6, 01.05.2018, p. 2357-2370.

Research output: Contribution to journalArticle

Luo, H, Yang, H, Gardiner, SK, Hardin, C, Sharpe, GP, Caprioli, J, Demirel, S, Girkin, CA, Liebmann, JM, Mardin, CY, Quigley, HA, Scheuerle, AF, Fortune, B, Chauhan, BC & Burgoyne, CF 2018, 'Factors influencing central lamina cribrosa depth: A multicenter study', Investigative Ophthalmology and Visual Science, vol. 59, no. 6, pp. 2357-2370. https://doi.org/10.1167/iovs.17-23456
Luo, Haomin ; Yang, Hongli ; Gardiner, Stuart K. ; Hardin, Christy ; Sharpe, Glen P. ; Caprioli, Joseph ; Demirel, Shaban ; Girkin, Christopher A. ; Liebmann, Jeffrey M. ; Mardin, Christian Y. ; Quigley, Harry A ; Scheuerle, Alexander F. ; Fortune, Brad ; Chauhan, Balwantray C. ; Burgoyne, Claude F. / Factors influencing central lamina cribrosa depth : A multicenter study. In: Investigative Ophthalmology and Visual Science. 2018 ; Vol. 59, No. 6. pp. 2357-2370.
@article{7aa96ac855b3482792b085a64e8fbd40,
title = "Factors influencing central lamina cribrosa depth: A multicenter study",
abstract = "PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89{\%}, range, 69{\%}-95{\%}). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.",
keywords = "Bruch’s membrane, Glaucoma, Laminar depth, Optic nerve head, Optical coherence tomography",
author = "Haomin Luo and Hongli Yang and Gardiner, {Stuart K.} and Christy Hardin and Sharpe, {Glen P.} and Joseph Caprioli and Shaban Demirel and Girkin, {Christopher A.} and Liebmann, {Jeffrey M.} and Mardin, {Christian Y.} and Quigley, {Harry A} and Scheuerle, {Alexander F.} and Brad Fortune and Chauhan, {Balwantray C.} and Burgoyne, {Claude F.}",
year = "2018",
month = "5",
day = "1",
doi = "10.1167/iovs.17-23456",
language = "English (US)",
volume = "59",
pages = "2357--2370",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "6",

}

TY - JOUR

T1 - Factors influencing central lamina cribrosa depth

T2 - A multicenter study

AU - Luo, Haomin

AU - Yang, Hongli

AU - Gardiner, Stuart K.

AU - Hardin, Christy

AU - Sharpe, Glen P.

AU - Caprioli, Joseph

AU - Demirel, Shaban

AU - Girkin, Christopher A.

AU - Liebmann, Jeffrey M.

AU - Mardin, Christian Y.

AU - Quigley, Harry A

AU - Scheuerle, Alexander F.

AU - Fortune, Brad

AU - Chauhan, Balwantray C.

AU - Burgoyne, Claude F.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.

AB - PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.

KW - Bruch’s membrane

KW - Glaucoma

KW - Laminar depth

KW - Optic nerve head

KW - Optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=85046650132&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046650132&partnerID=8YFLogxK

U2 - 10.1167/iovs.17-23456

DO - 10.1167/iovs.17-23456

M3 - Article

C2 - 29847642

AN - SCOPUS:85046650132

VL - 59

SP - 2357

EP - 2370

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 6

ER -