TY - JOUR
T1 - Factors influencing central lamina cribrosa depth
T2 - A multicenter study
AU - Luo, Haomin
AU - Yang, Hongli
AU - Gardiner, Stuart K.
AU - Hardin, Christy
AU - Sharpe, Glen P.
AU - Caprioli, Joseph
AU - Demirel, Shaban
AU - Girkin, Christopher A.
AU - Liebmann, Jeffrey M.
AU - Mardin, Christian Y.
AU - Quigley, Harry A.
AU - Scheuerle, Alexander F.
AU - Fortune, Brad
AU - Chauhan, Balwantray C.
AU - Burgoyne, Claude F.
N1 - Funding Information:
The authors thank Juan Reynaud (Devers Eye Institute) for his OCT technical assistance, Lirong Qin and Luke Ryes (Devers Eye Institute) for their help with reproducibility delineations, and Julia Monaghan (Devers Eye Institute) for assistance with manuscript preparation and submission. The authors thank the many technicians, fellows, and junior faculty at each participating study site that contributed to the data acquisition portion of this study. Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Baltimore, Maryland, United States, May 7–11, 2017. Supported by National Eye Institute Grants NIH/NEI R01-EY021281 (CFB) and NIH/NEI R01-EY-019674 (SD), with supplemental support from Legacy Good Samaritan Foundation and Heidelberg Engineering, GmbH (Heidelberg, Germany). Heidelberg Engineering funded image acquisition at each of the eight study centers. NIH/NEI R01-EY021281 funded manual segmentation data generation, analysis, and interpretation. Heidelberg Engineering provides additional unrestricted research support and technical assistance to CFB and BCC, but plays no role in data analysis, interpretation, presentation, or publication. The authors alone are responsible for the content and writing of this paper.
Funding Information:
Supported by National Eye Institute Grants NIH/NEI R01- EY021281 (CFB) and NIH/NEI R01-EY-019674 (SD), with supplemental support from Legacy Good Samaritan Foundation and Heidelberg Engineering, GmbH (Heidelberg, Germany). Heidelberg Engineering funded image acquisition at each of the eight study centers. NIH/NEI R01-EY021281 funded manual segmentation data generation, analysis, and interpretation. Heidelberg Engineering provides additional unrestricted research support and technical assistance to CFB and BCC, but plays no role in data analysis, interpretation, presentation, or publication. The authors alone are responsible for the content and writing of this paper.
Publisher Copyright:
© 2018 The Authors.
PY - 2018/5
Y1 - 2018/5
N2 - PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.
AB - PURPOSE. To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. METHODS. A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch’s membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. RESULTS. Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. CONCLUSIONS. Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.
KW - Bruch’s membrane
KW - Glaucoma
KW - Laminar depth
KW - Optic nerve head
KW - Optical coherence tomography
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U2 - 10.1167/iovs.17-23456
DO - 10.1167/iovs.17-23456
M3 - Article
C2 - 29847642
AN - SCOPUS:85046650132
SN - 0146-0404
VL - 59
SP - 2357
EP - 2370
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 6
ER -