Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P. Nieboer, E. G.E. de Vries, N. H. Mulder, S. Rodenhuis, M. Bontenbal, E. van der Wall, Q. G. van Hoesel, W. M. Smit, P. Hupperets, E. E. Voest, M. A. Nooij, H. M. Boezen, W. T.A. van der Graaf

Research output: Contribution to journalArticlepeer-review

Abstract

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia >10 days (P=0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P=<0.01), and use of total parenteral nutrition (TPN, P=0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalBone marrow transplantation
Volume42
Issue number7
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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