Factors in the release of vasopressin by the hypoxic fetus

S. S. Daniel, R. I. Stark, A. B. Zubrow, H. E. Fox, M. K. Husain, L. S. James

Research output: Contribution to journalArticle

Abstract

The relative effects of 3 stimuli in the release of vasopressin (VP) by the fetus were examined in 19 chronically instrumented fetal lambs, 118-135 days gestational age. The fetus was exposed to: 1) 3-min administration of 10% O2 to the pregnant ewe, 2) 20 min of partial occlusion of the umbilical cord, or 3) 2 min of complete occlusion of the umbilical cord. Twelve studies were conducted for each of these experimental protocols. The rises (mean ± SE) in plasma VP in the 3 groups were 29.9 ± 8.9, 48.9 ± 11.5, and 157.8 ± 12.5 pg/ml, respectively; the corresponding falls in PaO2 were 9.2 ± 0.7, 7.7 ± 0.9, and 12.7 ± 1.2 mm Hg. pHa did not change in the group receiving 10% O2, fell by 0.11 ± 0.02 and 0.14 ± 0.01 after partial and complete occlusion of the umbilical cord. The rises in mean arterial pressure were 6 ± 2.2, 10 ± 1.9, and 23 ± 3.1 mm Hg, respectively, at the end of the 3 procedures. The rise in plasma osmolality ranged from 2-8 mosmol/kg in all 3 groups. Linear regression analyses showed that log VP was negatively correlated with PaO2 (r = -0.827; P <0.01) and pHa (r = -0.706; P <0.01) and positively correlated to mean arterial pressure (r = 0.607; P = 0.01), but was not significantly correlated to plasma osmolality. Our present findings suggest that hypoxemia and acidemia are associated with and may both be potent stimuli for VP release in the hypoxic fetus. Increased release together with decreased rate of metabolism by the placenta offer an explanation for the very high VP levels found in the neonate after labor and delivery.

Original languageEnglish (US)
Pages (from-to)1623-1628
Number of pages6
JournalEndocrinology
Volume113
Issue number5
StatePublished - 1983
Externally publishedYes

Fingerprint

Vasopressins
Fetus
Umbilical Cord
Osmolar Concentration
Arterial Pressure
Placenta
Gestational Age
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Daniel, S. S., Stark, R. I., Zubrow, A. B., Fox, H. E., Husain, M. K., & James, L. S. (1983). Factors in the release of vasopressin by the hypoxic fetus. Endocrinology, 113(5), 1623-1628.

Factors in the release of vasopressin by the hypoxic fetus. / Daniel, S. S.; Stark, R. I.; Zubrow, A. B.; Fox, H. E.; Husain, M. K.; James, L. S.

In: Endocrinology, Vol. 113, No. 5, 1983, p. 1623-1628.

Research output: Contribution to journalArticle

Daniel, SS, Stark, RI, Zubrow, AB, Fox, HE, Husain, MK & James, LS 1983, 'Factors in the release of vasopressin by the hypoxic fetus', Endocrinology, vol. 113, no. 5, pp. 1623-1628.
Daniel SS, Stark RI, Zubrow AB, Fox HE, Husain MK, James LS. Factors in the release of vasopressin by the hypoxic fetus. Endocrinology. 1983;113(5):1623-1628.
Daniel, S. S. ; Stark, R. I. ; Zubrow, A. B. ; Fox, H. E. ; Husain, M. K. ; James, L. S. / Factors in the release of vasopressin by the hypoxic fetus. In: Endocrinology. 1983 ; Vol. 113, No. 5. pp. 1623-1628.
@article{a395e28b478c4117a653b073e2d3812f,
title = "Factors in the release of vasopressin by the hypoxic fetus",
abstract = "The relative effects of 3 stimuli in the release of vasopressin (VP) by the fetus were examined in 19 chronically instrumented fetal lambs, 118-135 days gestational age. The fetus was exposed to: 1) 3-min administration of 10{\%} O2 to the pregnant ewe, 2) 20 min of partial occlusion of the umbilical cord, or 3) 2 min of complete occlusion of the umbilical cord. Twelve studies were conducted for each of these experimental protocols. The rises (mean ± SE) in plasma VP in the 3 groups were 29.9 ± 8.9, 48.9 ± 11.5, and 157.8 ± 12.5 pg/ml, respectively; the corresponding falls in PaO2 were 9.2 ± 0.7, 7.7 ± 0.9, and 12.7 ± 1.2 mm Hg. pHa did not change in the group receiving 10{\%} O2, fell by 0.11 ± 0.02 and 0.14 ± 0.01 after partial and complete occlusion of the umbilical cord. The rises in mean arterial pressure were 6 ± 2.2, 10 ± 1.9, and 23 ± 3.1 mm Hg, respectively, at the end of the 3 procedures. The rise in plasma osmolality ranged from 2-8 mosmol/kg in all 3 groups. Linear regression analyses showed that log VP was negatively correlated with PaO2 (r = -0.827; P <0.01) and pHa (r = -0.706; P <0.01) and positively correlated to mean arterial pressure (r = 0.607; P = 0.01), but was not significantly correlated to plasma osmolality. Our present findings suggest that hypoxemia and acidemia are associated with and may both be potent stimuli for VP release in the hypoxic fetus. Increased release together with decreased rate of metabolism by the placenta offer an explanation for the very high VP levels found in the neonate after labor and delivery.",
author = "Daniel, {S. S.} and Stark, {R. I.} and Zubrow, {A. B.} and Fox, {H. E.} and Husain, {M. K.} and James, {L. S.}",
year = "1983",
language = "English (US)",
volume = "113",
pages = "1623--1628",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - Factors in the release of vasopressin by the hypoxic fetus

AU - Daniel, S. S.

AU - Stark, R. I.

AU - Zubrow, A. B.

AU - Fox, H. E.

AU - Husain, M. K.

AU - James, L. S.

PY - 1983

Y1 - 1983

N2 - The relative effects of 3 stimuli in the release of vasopressin (VP) by the fetus were examined in 19 chronically instrumented fetal lambs, 118-135 days gestational age. The fetus was exposed to: 1) 3-min administration of 10% O2 to the pregnant ewe, 2) 20 min of partial occlusion of the umbilical cord, or 3) 2 min of complete occlusion of the umbilical cord. Twelve studies were conducted for each of these experimental protocols. The rises (mean ± SE) in plasma VP in the 3 groups were 29.9 ± 8.9, 48.9 ± 11.5, and 157.8 ± 12.5 pg/ml, respectively; the corresponding falls in PaO2 were 9.2 ± 0.7, 7.7 ± 0.9, and 12.7 ± 1.2 mm Hg. pHa did not change in the group receiving 10% O2, fell by 0.11 ± 0.02 and 0.14 ± 0.01 after partial and complete occlusion of the umbilical cord. The rises in mean arterial pressure were 6 ± 2.2, 10 ± 1.9, and 23 ± 3.1 mm Hg, respectively, at the end of the 3 procedures. The rise in plasma osmolality ranged from 2-8 mosmol/kg in all 3 groups. Linear regression analyses showed that log VP was negatively correlated with PaO2 (r = -0.827; P <0.01) and pHa (r = -0.706; P <0.01) and positively correlated to mean arterial pressure (r = 0.607; P = 0.01), but was not significantly correlated to plasma osmolality. Our present findings suggest that hypoxemia and acidemia are associated with and may both be potent stimuli for VP release in the hypoxic fetus. Increased release together with decreased rate of metabolism by the placenta offer an explanation for the very high VP levels found in the neonate after labor and delivery.

AB - The relative effects of 3 stimuli in the release of vasopressin (VP) by the fetus were examined in 19 chronically instrumented fetal lambs, 118-135 days gestational age. The fetus was exposed to: 1) 3-min administration of 10% O2 to the pregnant ewe, 2) 20 min of partial occlusion of the umbilical cord, or 3) 2 min of complete occlusion of the umbilical cord. Twelve studies were conducted for each of these experimental protocols. The rises (mean ± SE) in plasma VP in the 3 groups were 29.9 ± 8.9, 48.9 ± 11.5, and 157.8 ± 12.5 pg/ml, respectively; the corresponding falls in PaO2 were 9.2 ± 0.7, 7.7 ± 0.9, and 12.7 ± 1.2 mm Hg. pHa did not change in the group receiving 10% O2, fell by 0.11 ± 0.02 and 0.14 ± 0.01 after partial and complete occlusion of the umbilical cord. The rises in mean arterial pressure were 6 ± 2.2, 10 ± 1.9, and 23 ± 3.1 mm Hg, respectively, at the end of the 3 procedures. The rise in plasma osmolality ranged from 2-8 mosmol/kg in all 3 groups. Linear regression analyses showed that log VP was negatively correlated with PaO2 (r = -0.827; P <0.01) and pHa (r = -0.706; P <0.01) and positively correlated to mean arterial pressure (r = 0.607; P = 0.01), but was not significantly correlated to plasma osmolality. Our present findings suggest that hypoxemia and acidemia are associated with and may both be potent stimuli for VP release in the hypoxic fetus. Increased release together with decreased rate of metabolism by the placenta offer an explanation for the very high VP levels found in the neonate after labor and delivery.

UR - http://www.scopus.com/inward/record.url?scp=0020629344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020629344&partnerID=8YFLogxK

M3 - Article

C2 - 6628319

AN - SCOPUS:0020629344

VL - 113

SP - 1623

EP - 1628

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 5

ER -