Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients

Ergun Velidedeoglu, Kevin C. Mange, Adam Frank, Peter Abt, Niraj M Desai, Joseph W. Markmann, Rajender Reddy, James F. Markmann

Research output: Contribution to journalArticle

Abstract

Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7%) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5% vs. 74.6% (P

Original languageEnglish (US)
Pages (from-to)1834-1842
Number of pages9
JournalTransplantation
Volume77
Issue number12
DOIs
StatePublished - Jun 27 2004
Externally publishedYes

Fingerprint

Hepacivirus
Liver Transplantation
Survival
Transplants
Liver
Graft Survival
Liver Diseases
Chronic Disease
Survival Rate
Databases

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients. / Velidedeoglu, Ergun; Mange, Kevin C.; Frank, Adam; Abt, Peter; Desai, Niraj M; Markmann, Joseph W.; Reddy, Rajender; Markmann, James F.

In: Transplantation, Vol. 77, No. 12, 27.06.2004, p. 1834-1842.

Research output: Contribution to journalArticle

Velidedeoglu, E, Mange, KC, Frank, A, Abt, P, Desai, NM, Markmann, JW, Reddy, R & Markmann, JF 2004, 'Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients', Transplantation, vol. 77, no. 12, pp. 1834-1842. https://doi.org/10.1097/01.TP.0000130468.36131.0D
Velidedeoglu, Ergun ; Mange, Kevin C. ; Frank, Adam ; Abt, Peter ; Desai, Niraj M ; Markmann, Joseph W. ; Reddy, Rajender ; Markmann, James F. / Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients. In: Transplantation. 2004 ; Vol. 77, No. 12. pp. 1834-1842.
@article{7601c1282d7b47f299927b55eb348883,
title = "Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients",
abstract = "Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7{\%}) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5{\%} vs. 74.6{\%} (P",
author = "Ergun Velidedeoglu and Mange, {Kevin C.} and Adam Frank and Peter Abt and Desai, {Niraj M} and Markmann, {Joseph W.} and Rajender Reddy and Markmann, {James F.}",
year = "2004",
month = "6",
day = "27",
doi = "10.1097/01.TP.0000130468.36131.0D",
language = "English (US)",
volume = "77",
pages = "1834--1842",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients

AU - Velidedeoglu, Ergun

AU - Mange, Kevin C.

AU - Frank, Adam

AU - Abt, Peter

AU - Desai, Niraj M

AU - Markmann, Joseph W.

AU - Reddy, Rajender

AU - Markmann, James F.

PY - 2004/6/27

Y1 - 2004/6/27

N2 - Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7%) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5% vs. 74.6% (P

AB - Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7%) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5% vs. 74.6% (P

UR - http://www.scopus.com/inward/record.url?scp=3042657300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042657300&partnerID=8YFLogxK

U2 - 10.1097/01.TP.0000130468.36131.0D

DO - 10.1097/01.TP.0000130468.36131.0D

M3 - Article

VL - 77

SP - 1834

EP - 1842

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 12

ER -