Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients

Ergun Velidedeoglu, Kevin C. Mange, Adam Frank, Peter Abt, Niraj M Desai, Joseph W. Markmann, Rajender Reddy, James F. Markmann

Research output: Contribution to journalArticle

Abstract

Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7%) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5% vs. 74.6% (P

Original languageEnglish (US)
Pages (from-to)1834-1842
Number of pages9
JournalTransplantation
Volume77
Issue number12
DOIs
StatePublished - Jun 27 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Velidedeoglu, E., Mange, K. C., Frank, A., Abt, P., Desai, N. M., Markmann, J. W., Reddy, R., & Markmann, J. F. (2004). Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients. Transplantation, 77(12), 1834-1842. https://doi.org/10.1097/01.TP.0000130468.36131.0D