Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients

Ergun Velidedeoglu, Kevin C. Mange, Adam Frank, Peter Abt, Niraj M. Desai, Joseph W. Markmann, Rajender Reddy, James F. Markmann

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Survival following liver transplantation for hepatitis C virus (HCV) is significantly poorer than for liver transplants performed for other causes of chronic liver disease. The factors responsible for the inferior outcome in HCV+ recipients, and whether they differ from factors associated with survival in HCV- recipients, are unknown. Methods. The UNOS database was analyzed to identify factors associated with outcome in HCV+ and HCV- recipients. Kaplan-Meier graft and patient survival and Cox proportional hazards analysis were conducted on 13,026 liver transplants to identify the variables that were differentially associated with outcome survival in HCV- and HCV+ recipients. Results. Of the 13,026 recipients, 7386 (56.7%) were HCV- and 5640 were HCV+. In HCV- and HCV+ recipient populations, five-year patient survival rates were 83.5% vs. 74.6% (P<0.00001) and five-year graft survival rates 89.6% vz 69.9% (P<0.00001), respectively. In a multivariate regression model, donor age and recipient creatinine were observed to be significant covariates in both groups, while donor race, cold ischemia time (CIT), female to male transplants, and recipient albumin were independent predictors of survival of HCV- recipients. In the HCV+ cohort, recipient race, warm ischemia, time (WIT), and diabetes also independently predicted graft survival. Conclusions. A number of parameters are differentially correlated with outcome in HCV- and HCV+ recipients of orthotopic liver transplantion. These findings may not only have practical implications in the selection and management of liver transplant patients, but also may shed new insight into the biology of HCV infection posttransplant.

Original languageEnglish (US)
Pages (from-to)1834-1842
Number of pages9
JournalTransplantation
Volume77
Issue number12
DOIs
StatePublished - Jun 27 2004
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Factors differentially correlated with the outcome of liver transplantation in HCV+ and HCV- recipients'. Together they form a unique fingerprint.

Cite this