Factors defining target specificity in antibody-mediated neuropathy: Density-dependent binding of anti-GD(1a) polyclonal IgG from a neurological patient

D. M. Kremer, P. H.H. López, R. K. Mizutamari, L. J. Kremer, E. A. Bacile, G. A. Nores

Research output: Contribution to journalArticlepeer-review

Abstract

IgM and IgG antibodies reacting with components of human brain gangliosides were detected in a patient bearing severe sensory ataxy. Using different chemical and immunological methods, the antigen was identified as the GD(1a) ganglioside. The antibodies showed antigen 'density-dependent' binding, a property only observed in tumor-specific monoclonal antibodies. The relevance of this result in regard with target specificity of neuropathy- associated antibodies directed to ubiquitous glycolipids is discussed.

Original languageEnglish (US)
Pages (from-to)636-641
Number of pages6
JournalJournal of neuroscience research
Volume47
Issue number6
DOIs
StatePublished - Mar 15 1997
Externally publishedYes

Keywords

  • antiganglioside antibodies
  • autoimmune neuropathy
  • density- dependent binding
  • gangliosides

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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