Factors controlling generation and propagation of pacemaker potentials in network models of mammalian SA node

Raimond L. Winslow, Dongming Cai, Ying Cheng Lai

Research output: Contribution to journalConference article

Abstract

Large-scale, biophysically detailed network models of the SA node and atrium are developed on the CM-5 parallel supercomputer. The models are used to investigate three factors controlling the site of generation and propagation of the cardiac pacemaker potential: a) magnitude of cell-to-cell gap junction coupling in the SA node; b) spatial variation of membrane current density in SA node; and c) interdigitation of SA node and atrial tissue.

Original languageEnglish (US)
Pages (from-to)560-569
Number of pages10
JournalProceedings of the ACM/IEEE Supercomputing Conference
StatePublished - Dec 1 1994
EventProceedings of the 1994 Supercomputing Conference - Washington, DC, USA
Duration: Nov 14 1994Nov 18 1994

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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