Factors associated with the prevalence and incidence of Trichomonas vaginalis infection among African American women in New York city who use drugs

Maureen Miller, Yuyan Liao, Anu Manchikanti Gomez, Charlotte A Gaydos, Delysha D'Mellow

Research output: Contribution to journalArticle

Abstract

Background. Trichomoniasis vaginalis, the most prevalent nonviral sexually transmitted infection, is associated with negative reproductive outcomes and increased HIV transmission and may be overrepresented among African Americans. Methods. Atotal of 135 African American women who used drugs were screened for Trichomonas vaginalis on ≥2 occasions between March 2003 and August 2005. Women were administered a structured questionnaire in a community-based research center, underwent serological testing for human immunodeficiency virus and herpes simplex virus type 2, and were screened for Neisseria gonorrhoeae and Chlamydia trachomatis. Results. Fifty-one women (38%) screened positive for T. vaginalis at baseline. Twenty-nine (31%) of 95 women with negative results of baseline tests became infected, for an incidence of 35.1 cases per 100 person-years at risk (95% confidence interval [CI], 23.5-49.0). Prevalent infection was associated with drug use in the past 30 days, and incident infection was associated with sexual behavior in the past 30 days, namely having >1 male sex partner. Women who reported having >1 partner were 4 times as likely as women with fewer partners to acquire T. vaginalis (hazard ratio, 4.3; 95% CI, 2.0-9.4). Conclusion. T. vaginalis may be endemic in this community of African American women. A control strategy that includes T. vaginalis screening in nonclinical settings and rapid point-of-care testing could contribute to the disruption of transmission of this pathogen.

Original languageEnglish (US)
Pages (from-to)503-509
Number of pages7
JournalJournal of Infectious Diseases
Volume197
Issue number4
DOIs
StatePublished - Feb 15 2008

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Trichomonas Infections
Trichomonas vaginalis
African Americans
Incidence
Pharmaceutical Preparations
HIV
Confidence Intervals
Infectious Disease Transmission
Human Herpesvirus 2
Neisseria gonorrhoeae
Chlamydia trachomatis
Sexually Transmitted Diseases
Infection
Sexual Behavior

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Factors associated with the prevalence and incidence of Trichomonas vaginalis infection among African American women in New York city who use drugs. / Miller, Maureen; Liao, Yuyan; Gomez, Anu Manchikanti; Gaydos, Charlotte A; D'Mellow, Delysha.

In: Journal of Infectious Diseases, Vol. 197, No. 4, 15.02.2008, p. 503-509.

Research output: Contribution to journalArticle

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abstract = "Background. Trichomoniasis vaginalis, the most prevalent nonviral sexually transmitted infection, is associated with negative reproductive outcomes and increased HIV transmission and may be overrepresented among African Americans. Methods. Atotal of 135 African American women who used drugs were screened for Trichomonas vaginalis on ≥2 occasions between March 2003 and August 2005. Women were administered a structured questionnaire in a community-based research center, underwent serological testing for human immunodeficiency virus and herpes simplex virus type 2, and were screened for Neisseria gonorrhoeae and Chlamydia trachomatis. Results. Fifty-one women (38{\%}) screened positive for T. vaginalis at baseline. Twenty-nine (31{\%}) of 95 women with negative results of baseline tests became infected, for an incidence of 35.1 cases per 100 person-years at risk (95{\%} confidence interval [CI], 23.5-49.0). Prevalent infection was associated with drug use in the past 30 days, and incident infection was associated with sexual behavior in the past 30 days, namely having >1 male sex partner. Women who reported having >1 partner were 4 times as likely as women with fewer partners to acquire T. vaginalis (hazard ratio, 4.3; 95{\%} CI, 2.0-9.4). Conclusion. T. vaginalis may be endemic in this community of African American women. A control strategy that includes T. vaginalis screening in nonclinical settings and rapid point-of-care testing could contribute to the disruption of transmission of this pathogen.",
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