Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda

Aaron A.R. Tobian, Blake Charvat, Victor Ssempijja, Godfrey Kigozi, David Serwadda, Frederick Makumbi, Boaz Iga, Oliver Laeyendecker, Melissa Riedesel, Amy Oliver, Michael Z. Chen, Steven J. Reynolds, Maria J. Wawer, Ronald H. Gray, Thomas C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)

Original languageEnglish (US)
Pages (from-to)945-949
Number of pages5
JournalJournal of Infectious Diseases
Volume199
Issue number7
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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