Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda

Aaron A.R. Tobian; Blake Charvat; Victor Ssempijja; Godfrey Kigozi; David Serwadda; Frederick Makumbi; Boaz Iga; Oliver Laeyendecker; Melissa Riedesel; Amy Oliver; Michael Z. Chen; Steven J. Reynolds; Maria J. Wawer; Ronald H. Gray; Thomas C. Quinn

doi:10.1086/597074

Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda

Aaron A.R. Tobian, Blake Charvat, Victor Ssempijja, Godfrey Kigozi, David Serwadda, Frederick Makumbi, Boaz Iga, Oliver Laeyendecker, Melissa Riedesel, Amy Oliver, Michael Z. Chen, Steven J. Reynolds, Maria J. Wawer, Ronald H. Gray, Thomas C. Quinn

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)

Original language	English (US)
Pages (from-to)	945-949
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	199
Issue number	7
DOIs	https://doi.org/10.1086/597074
State	Published - Apr 1 2009

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/597074

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Tobian, A. A. R., Charvat, B., Ssempijja, V., Kigozi, G., Serwadda, D., Makumbi, F., Iga, B., Laeyendecker, O., Riedesel, M., Oliver, A., Chen, M. Z., Reynolds, S. J., Wawer, M. J., Gray, R. H., & Quinn, T. C. (2009). Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda. Journal of Infectious Diseases, 199(7), 945-949. https://doi.org/10.1086/597074

Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda. / Tobian, Aaron A.R.; Charvat, Blake; Ssempijja, Victor; Kigozi, Godfrey; Serwadda, David; Makumbi, Frederick; Iga, Boaz; Laeyendecker, Oliver; Riedesel, Melissa; Oliver, Amy; Chen, Michael Z.; Reynolds, Steven J.; Wawer, Maria J.; Gray, Ronald H.; Quinn, Thomas C.

In: Journal of Infectious Diseases, Vol. 199, No. 7, 01.04.2009, p. 945-949.

Research output: Contribution to journal › Article › peer-review

Tobian, AAR, Charvat, B, Ssempijja, V, Kigozi, G, Serwadda, D, Makumbi, F, Iga, B, Laeyendecker, O, Riedesel, M, Oliver, A, Chen, MZ, Reynolds, SJ , Wawer, MJ , Gray, RH & Quinn, TC 2009, 'Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda', Journal of Infectious Diseases, vol. 199, no. 7, pp. 945-949. https://doi.org/10.1086/597074

Tobian, Aaron A.R. ; Charvat, Blake ; Ssempijja, Victor ; Kigozi, Godfrey ; Serwadda, David ; Makumbi, Frederick ; Iga, Boaz ; Laeyendecker, Oliver ; Riedesel, Melissa ; Oliver, Amy ; Chen, Michael Z. ; Reynolds, Steven J. ; Wawer, Maria J. ; Gray, Ronald H. ; Quinn, Thomas C. / Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda. In: Journal of Infectious Diseases. 2009 ; Vol. 199, No. 7. pp. 945-949.

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title = "Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda",

abstract = "Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)",

author = "Tobian, {Aaron A.R.} and Blake Charvat and Victor Ssempijja and Godfrey Kigozi and David Serwadda and Frederick Makumbi and Boaz Iga and Oliver Laeyendecker and Melissa Riedesel and Amy Oliver and Chen, {Michael Z.} and Reynolds, {Steven J.} and Wawer, {Maria J.} and Gray, {Ronald H.} and Quinn, {Thomas C.}",

note = "Funding Information: Financial support: National Institutes of Health (grant U1AI51171 to the trials); Bill and Melinda Gates Foundation (grant 22006.02 to the trials); Fogarty International Center (grants 5D43TW001508 and D43TW00015 to the trials); Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (support to this study). a T.C.Q. and R.H.G. share senior authorship. Reprints or correspondence: Dr. Aaron A. R. Tobian, 855 N. Wolfe St., Rm. 527, Baltimore, MD 21205 (atobian1@jhmi.edu).",

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T1 - Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in rakai, uganda

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AU - Ssempijja, Victor

AU - Kigozi, Godfrey

AU - Serwadda, David

AU - Makumbi, Frederick

AU - Iga, Boaz

AU - Laeyendecker, Oliver

AU - Riedesel, Melissa

AU - Oliver, Amy

AU - Chen, Michael Z.

AU - Reynolds, Steven J.

AU - Wawer, Maria J.

AU - Gray, Ronald H.

AU - Quinn, Thomas C.

N1 - Funding Information: Financial support: National Institutes of Health (grant U1AI51171 to the trials); Bill and Melinda Gates Foundation (grant 22006.02 to the trials); Fogarty International Center (grants 5D43TW001508 and D43TW00015 to the trials); Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (support to this study). a T.C.Q. and R.H.G. share senior authorship. Reprints or correspondence: Dr. Aaron A. R. Tobian, 855 N. Wolfe St., Rm. 527, Baltimore, MD 21205 (atobian1@jhmi.edu).

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N2 - Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)

AB - Little is known about risk factors for incident herpes simplex virus type 2 (HSV-2) infection among men in Africa. In a trial in Rakai, Uganda, 6396 men aged 15-49 years were evaluated for serological evidence of HSV-2, human immunodeficiency virus (HIV), and syphilis infections at enrollment and at 6, 12, and 24 months. The prevalence of HSV-2 infection was 33.76%, and the incidence was 4.90 cases per 100 person-years. HSV-2 incidence increased with alcohol use with sexual intercourse (adjusted incidence rate ratio [adjIRR], 1.92 [95% confidence interval {CI}, 1.46-2.53]), decreased with consistent condom use (adjIRR, 0.56 [95% CI, 0.36-0.89]) and male circumcision (adjIRR, 0.70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878.)

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