Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

Ricardo R. Oliveira, Joanemile P. Figueiredo, Luciana S. Cardoso, Rafael L. Jabar, Robson P. Souza, Martin T. Wells, Edgar M. Carvalho, Daniel W. Fitzgerald, Kathleen C. Barnes, Maria Ilma Araújo, Marshall J. Glesby

Research output: Contribution to journalArticlepeer-review

Abstract

Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult wormantigen (SWAP) and against interleukin- 4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.

Original languageEnglish (US)
Pages (from-to)296-305
Number of pages10
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume86
Issue number2
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Fingerprint Dive into the research topics of 'Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil'. Together they form a unique fingerprint.

Cite this