TY - JOUR
T1 - Factors associated with multiple recurrences of nonspecific orbital inflammation aka orbital pseudotumor
AU - Braich, Puneet S.
AU - Kuriakose, Robin K.
AU - Khokhar, Naveen S.
AU - Donaldson, Jared C.
AU - McCulley, Timothy J.
N1 - Funding Information:
We would like to express our gratitude to the clinical staff at the KD Dalmia Eye Hospital and the Balwant Singh Charitable hospital for their efforts in translating the medical record, data acquisition, and acting as a liaison for outside health centers. None of the authors have any proprietary interests or conflicts of interest related to this submission.
Publisher Copyright:
© 2017, Springer Science+Business Media B.V.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objective: To assess clinical characteristics of patients at risk for recurrent nonspecific orbital inflammation (NSOI). Methods: This was a retrospective comparison study with a 24-month follow-up, in a clinic-based population in rural India. The medical records at two eye care centers were searched from March 2001–2014. A total of 153 patients with recurrent NSOI, 107 of whom had a single recurrence (Group 1) and 46 of whom had multiple recurrences (Group 2). Clinical and demographic data were compared between both groups. Comparisons of mean values were done with multiple 2-tailed independent T tests, and differences in proportions were compared using Chi-squared tests. A multivariate logistic regression model was used to determine which factors were predictive of patients having multiple recurrences. Results: Several factors were independently related to multiple recurrences (P < 0.05 for all): age ≤16 years (2.5 OR, 95% CI 1.3–3.6), bilateral disease (3.2 OR 95% CI 1.4–5.1), presence of optic disc edema or T-sign on B-scan ultrasonography (3.9 OR 95% CI 1.8–6.2), sclerosing variant (8.5 OR 95% CI 5.4–11.3), corticosteroid taper <4 weeks long (2.8 OR 95% CI 1.1–4.2), autoimmune disease among 1st degree relatives (2.2 OR 95% CI 1.2–3.3). In patients with recurrent disease, the interval between the initial episode and the first recurrence was predictive of further recurrences: ≤3 months (3.2 OR, 95% CI 2.0–4.5) and ≥12 months (0.21 OR, 95% CI 0.01–0.39). Conclusion: Younger patients and those with bilateral disease are more apt to have recurrences of NSOI. Other factors that increase the risk of multiple recurrences include a T-sign, optic disc edema, poor initial response to steroids, a sclerosing variant, a recurrence within 3 months, and those who underwent a rapid steroid taper.
AB - Objective: To assess clinical characteristics of patients at risk for recurrent nonspecific orbital inflammation (NSOI). Methods: This was a retrospective comparison study with a 24-month follow-up, in a clinic-based population in rural India. The medical records at two eye care centers were searched from March 2001–2014. A total of 153 patients with recurrent NSOI, 107 of whom had a single recurrence (Group 1) and 46 of whom had multiple recurrences (Group 2). Clinical and demographic data were compared between both groups. Comparisons of mean values were done with multiple 2-tailed independent T tests, and differences in proportions were compared using Chi-squared tests. A multivariate logistic regression model was used to determine which factors were predictive of patients having multiple recurrences. Results: Several factors were independently related to multiple recurrences (P < 0.05 for all): age ≤16 years (2.5 OR, 95% CI 1.3–3.6), bilateral disease (3.2 OR 95% CI 1.4–5.1), presence of optic disc edema or T-sign on B-scan ultrasonography (3.9 OR 95% CI 1.8–6.2), sclerosing variant (8.5 OR 95% CI 5.4–11.3), corticosteroid taper <4 weeks long (2.8 OR 95% CI 1.1–4.2), autoimmune disease among 1st degree relatives (2.2 OR 95% CI 1.2–3.3). In patients with recurrent disease, the interval between the initial episode and the first recurrence was predictive of further recurrences: ≤3 months (3.2 OR, 95% CI 2.0–4.5) and ≥12 months (0.21 OR, 95% CI 0.01–0.39). Conclusion: Younger patients and those with bilateral disease are more apt to have recurrences of NSOI. Other factors that increase the risk of multiple recurrences include a T-sign, optic disc edema, poor initial response to steroids, a sclerosing variant, a recurrence within 3 months, and those who underwent a rapid steroid taper.
KW - Idiopathic orbital inflammation
KW - Nonspecific orbital inflammation
KW - Orbital inflammatory disease
KW - Orbital pseudotumor
KW - Risk factors for multiple recurrences
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U2 - 10.1007/s10792-017-0610-7
DO - 10.1007/s10792-017-0610-7
M3 - Article
C2 - 28634929
AN - SCOPUS:85021176891
SN - 0165-5701
VL - 38
SP - 1485
EP - 1495
JO - International Ophthalmology
JF - International Ophthalmology
IS - 4
ER -