Factors associated with mortality in transplant patients with invasive aspergillosis

John W. Baddley, David R. Andes, Kieren Marr, Dimitrios P. Kontoyiannis, Barbara D. Alexander, Carol A. Kauffman, Robert A. Oster, Elias J. Anaissie, Thomas J. Walsh, Mindy G. Schuster, John R. Wingard, Thomas F. Patterson, James I. Ito, O. Dale Williams, Tom Chiller, Peter G. Pappas

Research output: Contribution to journalArticle

Abstract

Background. Invasive aspergillosis (IA) is an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. The purpose of this study was to evaluate factors associated with mortality in transplant patients with IA. Methods. Transplant patients from 23 US centers were enrolled from March 2001 to October 2005 as part of the Transplant Associated Infection Surveillance Network. IA cases were identified prospectively in this cohort through March 2006, and data were collected. Factors associated with 12-week all-cause mortality were determined by logistic regression analysis and Cox proportional hazards regression. Results. Six-hundred forty-two cases of proven or probable IA were evaluated, of which 317 (49.4%) died by the study endpoint. All-cause mortality was greater in HSCT patients (239 [57.5%] of 415) than in SOT patients (78 [34.4%] of 227; P

Original languageEnglish (US)
Pages (from-to)1559-1567
Number of pages9
JournalClinical Infectious Diseases
Volume50
Issue number12
DOIs
StatePublished - Jun 15 2010

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Aspergillosis
Transplants
Mortality
Hematopoietic Stem Cells
Logistic Models
Regression Analysis
Morbidity
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Baddley, J. W., Andes, D. R., Marr, K., Kontoyiannis, D. P., Alexander, B. D., Kauffman, C. A., ... Pappas, P. G. (2010). Factors associated with mortality in transplant patients with invasive aspergillosis. Clinical Infectious Diseases, 50(12), 1559-1567. https://doi.org/10.1086/652768

Factors associated with mortality in transplant patients with invasive aspergillosis. / Baddley, John W.; Andes, David R.; Marr, Kieren; Kontoyiannis, Dimitrios P.; Alexander, Barbara D.; Kauffman, Carol A.; Oster, Robert A.; Anaissie, Elias J.; Walsh, Thomas J.; Schuster, Mindy G.; Wingard, John R.; Patterson, Thomas F.; Ito, James I.; Williams, O. Dale; Chiller, Tom; Pappas, Peter G.

In: Clinical Infectious Diseases, Vol. 50, No. 12, 15.06.2010, p. 1559-1567.

Research output: Contribution to journalArticle

Baddley, JW, Andes, DR, Marr, K, Kontoyiannis, DP, Alexander, BD, Kauffman, CA, Oster, RA, Anaissie, EJ, Walsh, TJ, Schuster, MG, Wingard, JR, Patterson, TF, Ito, JI, Williams, OD, Chiller, T & Pappas, PG 2010, 'Factors associated with mortality in transplant patients with invasive aspergillosis', Clinical Infectious Diseases, vol. 50, no. 12, pp. 1559-1567. https://doi.org/10.1086/652768
Baddley JW, Andes DR, Marr K, Kontoyiannis DP, Alexander BD, Kauffman CA et al. Factors associated with mortality in transplant patients with invasive aspergillosis. Clinical Infectious Diseases. 2010 Jun 15;50(12):1559-1567. https://doi.org/10.1086/652768
Baddley, John W. ; Andes, David R. ; Marr, Kieren ; Kontoyiannis, Dimitrios P. ; Alexander, Barbara D. ; Kauffman, Carol A. ; Oster, Robert A. ; Anaissie, Elias J. ; Walsh, Thomas J. ; Schuster, Mindy G. ; Wingard, John R. ; Patterson, Thomas F. ; Ito, James I. ; Williams, O. Dale ; Chiller, Tom ; Pappas, Peter G. / Factors associated with mortality in transplant patients with invasive aspergillosis. In: Clinical Infectious Diseases. 2010 ; Vol. 50, No. 12. pp. 1559-1567.
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AU - Kontoyiannis, Dimitrios P.

AU - Alexander, Barbara D.

AU - Kauffman, Carol A.

AU - Oster, Robert A.

AU - Anaissie, Elias J.

AU - Walsh, Thomas J.

AU - Schuster, Mindy G.

AU - Wingard, John R.

AU - Patterson, Thomas F.

AU - Ito, James I.

AU - Williams, O. Dale

AU - Chiller, Tom

AU - Pappas, Peter G.

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